Association Between Telomere Length and Cardiac Dysfunction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-01

Study Completion Date

2020-05-01

Brief Summary

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Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.

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Detailed Description

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Conditions

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Cardiac Toxicity Acute Leukemia Childhood Cancer

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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acute leukemia group

300 patients were recruited, who have diagnosed with acute leukemia by bone marrow biopsy

Relative telomere length

Intervention Type DIAGNOSTIC_TEST

Relative telomere length in peripheral blood cell

Interventions

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Relative telomere length

Relative telomere length in peripheral blood cell

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* 1\. histological confirmed acute leukemia; 2. Preparing for chemotherapy;

Exclusion Criteria

* 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Minimum Eligible Age

1 Year

Maximum Eligible Age

16 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes