The Influences of Malnutrition and Inflammation Complex Syndrome in Hemodialysis Patients

NCT ID: NCT00190125

Last Updated: 2009-02-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Completion Date

2007-08-31

Brief Summary

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The purpose of this study is to explore the severity of malnutrition and inflammation in Taiwanese hemodialysis patients.

Detailed Description

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Cardiovascular disease is the major of cause of mortality of hemodialysis patients. In addition to diabetes and hypertension, malnutrition and chronic inflammation are well-known to be major risk factors of cardiovascular diseases in normal population. For detecting the malnutrition and chronic inflammation and understanding the exact influences to hemodialysis patients, we conduct this study. We will collect the biochemical parameters, inflammatory markers, lipid parameters, hematologic parameters, and genomic DNA of patients. Then we will prospectively record the hospitalization, cardiovascular events, complications of arteriovenous fistula/graft, and mortality. According to the above results, we try to explore the exact role of malnutrition and inflammation in hemodialysis patients.

Conditions

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Hemodialysis Malnutrition Inflammation Myocardial Ischemia Cerebrovascular Accident

Study Design

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Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Patients who have received hemodialysis therapy for more than three months

Exclusion Criteria

* Having active infection diseases now
* Patients who have a malignancy
* Had cardiovascular events in recent three months
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University

OTHER

Sponsor Role collaborator

Far Eastern Memorial Hospital

OTHER

Sponsor Role lead

Principal Investigators

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Yu-Sen Peng, M.D.

Role: PRINCIPAL_INVESTIGATOR

Far Eastern Memorial Hospital

Locations

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Far Eastern Memorial Hospital

Pan-Chiao, Taipei Country, , Taiwan

Site Status

Countries

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Taiwan

Central Contacts

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Yu-Sen Peng, M.D.

Role: CONTACT

886-2-89667000 ext. 1514

Chih-Kang Chiang, M.D.

Role: CONTACT

886-2-23123456 ext. 3923

Facility Contacts

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Yu-Sen Peng, M.D.

Role: primary

886-89667000 ext. 1514

References

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Kalantar-Zadeh K, Ikizler TA, Block G, Avram MM, Kopple JD. Malnutrition-inflammation complex syndrome in dialysis patients: causes and consequences. Am J Kidney Dis. 2003 Nov;42(5):864-81. doi: 10.1016/j.ajkd.2003.07.016.

Reference Type BACKGROUND
PMID: 14582032 (View on PubMed)

Kalantar-Zadeh K, Kopple JD, Block G, Humphreys MH. Association among SF36 quality of life measures and nutrition, hospitalization, and mortality in hemodialysis. J Am Soc Nephrol. 2001 Dec;12(12):2797-2806. doi: 10.1681/ASN.V12122797.

Reference Type BACKGROUND
PMID: 11729250 (View on PubMed)

Kalantar-Zadeh K, McAllister CJ, Lehn RS, Lee GH, Nissenson AR, Kopple JD. Effect of malnutrition-inflammation complex syndrome on EPO hyporesponsiveness in maintenance hemodialysis patients. Am J Kidney Dis. 2003 Oct;42(4):761-73. doi: 10.1016/s0272-6386(03)00915-6.

Reference Type BACKGROUND
PMID: 14520627 (View on PubMed)

Kalantar-Zadeh K, Block G, McAllister CJ, Humphreys MH, Kopple JD. Appetite and inflammation, nutrition, anemia, and clinical outcome in hemodialysis patients. Am J Clin Nutr. 2004 Aug;80(2):299-307. doi: 10.1093/ajcn/80.2.299.

Reference Type BACKGROUND
PMID: 15277149 (View on PubMed)

Kalantar-Zadeh K, Mehrotra R, Fouque D, Kopple JD. Metabolic acidosis and malnutrition-inflammation complex syndrome in chronic renal failure. Semin Dial. 2004 Nov-Dec;17(6):455-65. doi: 10.1111/j.0894-0959.2004.17606.x.

Reference Type BACKGROUND
PMID: 15660576 (View on PubMed)

Other Identifiers

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FEMH-94008

Identifier Type: -

Identifier Source: org_study_id

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