The Association Between Areca-nut Chewing Habit and Metabolic Syndrome

NCT ID: NCT02175524

Last Updated: 2014-06-26

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 200 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2014-04-30

Brief Summary

The purpose of this study is going to determine the odds ratio of metabolic syndrome (MS), the habit of areca nut chewing, antioxidant, and inflammatory status in oral and esophageal patients. The current study was designed as a case-control study. Patients proved to be oral and esophageal cancer and had the habit of areca nut chewing are defined as case group. Patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing are defined as control group. The participants' age, blood pressures, and smoking habits will be recorded. Body weight, height, waist, and hip circumferences will be measured. Fasting venous blood samples will be obtained to determine hematological parameters [i.e., serum creatinine, total cholesterol, triacylglycerol, low density lipoprotein-cholesterol, high density lipoprotein-cholesterol, malondialdehyde, superoxide dismutase, glutathione peroxidase, catalase, and inflammatory markers (C-reactive protein, tumor necrosis factor-alpha, and interleukin-6)]. Logistic regression analyses are going to perform to examine the relationship between areca nut chewing and MS in this population. If we can make sure the relationship between areca nut chewing and MS, the clinicians and nutritionists can teach people to quit areca nut chewing in order to avoid the possibility of developing metabolic syndrome and cardiovascular disease.

Conditions

Oral and Esophageal Cancer; Metabolic Syndrome.

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Case

Patients proved to be oral and esophageal cancer and had the habit of areca nut chewing.

No interventions assigned to this group

Control

Patients proved to be oral and esophageal cancer and did not have the habit of areca nut chewing.

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

• Patients proved to be oral and esophageal cancer will be recruited.

Exclusion Criteria

• Subjects with diabetes mellitus, liver, renal diseases, or undergoing statin therapy.
• Taking antioxidant vitamins supplements.

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Taichung Veterans General Hospital

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Taichung Verterans General Hospital

Taichung, , Taiwan

Site Status: RECRUITING

Countries

Taiwan

Central Contacts

Ping-Ting Lin, Ph.D.

Role: CONTACT

apt810@csmu.edu.tw

+886-4-23470022 ext. 12187

Bore-Jen Lee, Ph.D.

Role: CONTACT

borjen@vghtc.gov.tw

+886-4-23592525 ext. 3190

Facility Contacts

Ping-Ting Lin, Ph.D.

Role: primary

apt810@csmu.edu.tw

+886-24730022 ext. 12187

Bore-Jen Lee, Ph.D.

Role: backup

borjen@vghtc.gov.tw

+886-23592525 ext. 3190

Other Identifiers

CF13341

Identifier Type: -

Identifier Source: org_study_id