The Relationship Between Arsenic Methylation Capability and Blood Metals in Children With Developmental Delays

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

137 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-03-31

Study Completion Date

2011-07-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to explore the relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of life.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Genetic Biomarkers Associated With Child Language Development in Taiwan (II)

NCT05510570

Child Language

COMPLETED

Genetic Biomarkers Associated With Child Language Development in Taiwan

NCT04518787

Child Language

UNKNOWN

Genetic Biomarkers of Child Language Development in Taiwan: an Identification and Validation Study

NCT05504564

Child Language

UNKNOWN

Child Development and Genetic Biomarkers

NCT04660942

Child Development

UNKNOWN

Clinical and Genetic Study of Autism Spectrum Disorder

NCT00494754

Autism

COMPLETED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The investigators recruited children with developmental delays and children with normal development from Shin-Kong Ho-Su Memorial Hospital as controls. Information obtained from the interview included socioeconomic and basic demographic characteristics as well as children function, health condition, and quality of life. On the other hand, blood and urine samples of the participants were collected for the analysis of arsenic methylation related enzymes using polymerase chain reaction and restriction fragment length polymorphism. 2 ml blood were digested for the determination of mercury, lead and arsenic. The relationship between arsenic methylation and blood metals in children with developmental delays and its correlation with health related quality of were analyzed.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Developmental Delays

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

study group

children confirmed to have developmental delays

study group

Intervention Type OTHER

Explore the relationship of heavy metals and health related quality of life, including the relationship between the developmental delays and polymorphism of arsenic methylation enzymes, arsenic methylation capability and blood metals. Identify the interaction of children function, health condition, and quality of life and arsenic methylation and blood metals in children with developmental delays.

control group

children with typical development

study group

Intervention Type OTHER

Explore the relationship of heavy metals and health related quality of life, including the relationship between the developmental delays and polymorphism of arsenic methylation enzymes, arsenic methylation capability and blood metals. Identify the interaction of children function, health condition, and quality of life and arsenic methylation and blood metals in children with developmental delays.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

study group

Explore the relationship of heavy metals and health related quality of life, including the relationship between the developmental delays and polymorphism of arsenic methylation enzymes, arsenic methylation capability and blood metals. Identify the interaction of children function, health condition, and quality of life and arsenic methylation and blood metals in children with developmental delays.

Intervention Type OTHER

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* children with developmental delays obtained written informed consent from parents

* children with normal development obtained written informed consent from parents

Exclusion Criteria

* parents refused for participation of their children to the intervention failed to obtain the written informed consent from parents

Control group:

* parents refused for participation of their children to the intervention failed to obtain the written informed consent from parents

Minimum Eligible Age

2 Years

Maximum Eligible Age

12 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes