Social Cognition in Patients With Amyotrophic Lateral Sclerosis

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

74 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-21

Study Completion Date

2023-09-30

Brief Summary

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Amyotrophic Lateral Sclerosis, also known as Charcot disease, is a neurodegenerative disease evidenced by gradual paralysis of the muscles involved in voluntary motor function. The clinical hallmark of Amyotrophic Lateral Sclerosis is the combination of upper and lower motor neuron signs and symptoms. The most recent studies suggest that up to 50% of Amyotrophic Lateral Sclerosis patients demonstrate mild to moderate cognitive disturbance. Impaired social cognition, including a deficit in the recognition of facial emotions and the identification of vocal prosody, is recognized as a part of the cognitive phenotype of Amyotrophic Lateral Sclerosis, with crucial implications for patients' and caregivers' training. However, studies remain scarce and the data acquired must be supported. The evolution of these manifestations during the disease is still poorly understood.

In this study the investigators aim to assess the social cognition capacities of patients with Amyotrophic Lateral Sclerosis compared to healthy matched control subjects.

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Detailed Description

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Conditions

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Social Cognition

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Patients Amyotrophic Lateral Sclerosis

Group Type OTHER

neuropsychological test

Intervention Type OTHER

neuropsychological test

Control subjects

Group Type OTHER

neuropsychological test

Intervention Type OTHER

neuropsychological test

Interventions

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neuropsychological test

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

Patient Amyotrophic Lateral Sclerosis :

* Education of at least 7 years
* Native language: French
* Patients Amyotrophic Lateral Sclerosis
* Signature of informed consent to participate in the study
* Accompanied patient

Control subject :

* People without any pathology
* Education of at least 7 years
* Native language: French
* Signature of informed consent to participate in the study

Exclusion Criteria

Patient Amyotrophic Lateral Sclerosis and control subject :

* Simultaneous participation in another interventional protocol with experimental treatment
* Inability to perform cognitive study tests
* Pregnant, lactating or parturient women
* Persons deprived of their liberty by administrative or judicial decision
* Persons under psychiatric care under duress
* Persons subject to legal protection measures
* Persons out of state to express their consent
* People not affiliated or not beneficiaries of a social security scheme
* History likely to disturb cognition

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes