Utilization of Donor Whole Blood for Blood Transfusion in Deceased Donor Liver Transplantation
NCT ID: NCT04383756
Last Updated: 2022-03-09
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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WITHDRAWN
EARLY_PHASE1
INTERVENTIONAL
2020-12-31
2021-07-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Donor Blood
Between 2-4 units of donor leukoreduced whole blood (each unit will contain up to 350mL) transfused as needed in Liver transplantation participants
Donor Blood
Up to 4 units (each unit contains 350mL) of leukoreduced donor whole blood
Banked Blood
Standard of Care - Up to 350mL Allogenic banked component blood transfusion in a 1:1:1 manner (packed red blood cells : plasma : platelets) transfused as needed in Liver transplantation participants
Banked Blood
Up to 350mL of Allogenic banked component blood transfusion in a 1:1:1 manner (packed red blood cells : plasma : platelets)
Interventions
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Donor Blood
Up to 4 units (each unit contains 350mL) of leukoreduced donor whole blood
Banked Blood
Up to 350mL of Allogenic banked component blood transfusion in a 1:1:1 manner (packed red blood cells : plasma : platelets)
Eligibility Criteria
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Inclusion Criteria
* Deceased donor whole graft liver transplant recipients undergoing liver transplant starting 07/01/2020 and onwards at VUMC.
* ABO-matched recipient and donor.
* Donor Hb level \>/= 8 g/dL
* Recipients with negative ABO antibody screen
Exclusion Criteria
* HBS Antigen+ donors
* HCV NAT+ donors
* Donors of A2 blood type
* Donors on oral anticoagulants (except for aspirin) over the past 3 days before organ procurement
18 Years
ALL
No
Sponsors
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Vanderbilt University Medical Center
OTHER
Responsible Party
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Principal Investigators
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Clayne Benson, MD
Role: PRINCIPAL_INVESTIGATOR
Vanderbilt University Medical Center
Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, United States
Countries
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Other Identifiers
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UDWBBT
Identifier Type: -
Identifier Source: org_study_id
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