Impact of Augmenting Exercise Intensity vs. Frequency

NCT ID: NCT04295590

Last Updated: 2020-03-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

16 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-09-30

Study Completion Date

2020-04-10

Brief Summary

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The purpose of this study is to compare the impact of augmenting exercise intensity and augmenting exercise frequency on peak work rate. Participants will complete exercise tests and provide 8 skeletal muscle samples following a within-subjects randomized crossover design utilizing single-leg cycling. Both training periods will be 4 weeks long and skeletal muscle biopsies will be collected from both legs before and after each training period. All exercise sessions will be supervised, take place in the investigator's laboratory, and occur on stationary bikes.

Detailed Description

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Conditions

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Exercise Training

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Outcome Assessors

Study Groups

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Frequency then Intensity

Training period 1: Frequency comparison Training period 2: Intensity comparison

Group Type EXPERIMENTAL

Frequency comparison

Intervention Type BEHAVIORAL

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).

Intensity comparison

Intervention Type BEHAVIORAL

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).

Intensity then Frequency

Training period 1: Intensity comparison Training period 2: Frequency comparison

Group Type EXPERIMENTAL

Frequency comparison

Intervention Type BEHAVIORAL

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).

Intensity comparison

Intervention Type BEHAVIORAL

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).

Interventions

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Frequency comparison

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to high-frequency low-intensity (5 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery).

Intervention Type BEHAVIORAL

Intensity comparison

One leg assigned to low-frequency low-intensity (3 days per week of 11 x 1 min @ 73% peak work rate interspersed with 1-minute periods of active recovery). The other leg assigned to low-frequency high-intensity (3 days per week of 8 x 1 min @ 100% peak work rate interspersed with 1-minute periods of active recovery).

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Recreational active (\<3 hours per week of aerobic exercise)
* Willing to provide skeletal muscle biopsies

Exclusion Criteria

* Cardiovascular or metabolic disease
* Athletes or individuals exceeding 3 hours per week of aerobic exercise
* Smokers
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Queen's University

OTHER

Sponsor Role collaborator

Brendon Gurd, PhD

OTHER

Sponsor Role lead

Responsible Party

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Brendon Gurd, PhD

Professor, School of Kinesiology & Health Studies, Queen's University

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Brendon J Gurd, PhD

Role: PRINCIPAL_INVESTIGATOR

Queen's University

Locations

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Queen's Muscle Physiology Lab in the School of Kinesiology and Health Studies at Queen's University

Kingston, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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UCD Study

Identifier Type: -

Identifier Source: org_study_id

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