Non-invasive Nerve Stimulation and Cognitive Training to Improve Cognitive Performance in Healthy Older Adults
NCT ID: NCT04276805
Last Updated: 2025-05-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
7 participants
INTERVENTIONAL
2020-11-17
2025-10-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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tVNS group
Participants will undergo cognitive training with tVNS
Transcutaneous vagal nerve stimulation (tVNS)
a non-invasive and safe technique that transiently enhances brain GABA and noradrenaline levels.
cognitive training
A program of regular mental activities purported to maintain or improve one's cognitive abilities.
Sham group
Participants will undergo cognitive training with earlobe sham
cognitive training
A program of regular mental activities purported to maintain or improve one's cognitive abilities.
Interventions
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Transcutaneous vagal nerve stimulation (tVNS)
a non-invasive and safe technique that transiently enhances brain GABA and noradrenaline levels.
cognitive training
A program of regular mental activities purported to maintain or improve one's cognitive abilities.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Evidence of dementia .
* Major psychiatric illness
* Unstable and chronic medical conditions.
* MRI contraindications (e.g., pregnancy, claustrophobia, metal implants that are contraindicated for MRI).
* Physical impairment precluding motor response or lying still or walking
* Hearing or vision deficits that will not allow for completion of assessments
65 Years
90 Years
ALL
Yes
Sponsors
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University of Arizona
OTHER
University of Florida
OTHER
Responsible Party
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Principal Investigators
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John Williamson, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Florida
Locations
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University of Arizona
Tucson, Arizona, United States
University of Florida
Gainesville, Florida, United States
Countries
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Other Identifiers
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IRB201902991
Identifier Type: -
Identifier Source: org_study_id
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