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Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage

NCT ID: NCT04275674

Last Updated: 2022-10-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

57 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-08-01

Study Completion Date

2023-07-31

Brief Summary

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The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation. Obesity is associated with an increased risk of recurrent miscarriage (RM), but the underlying mechanisms are unclear. Abnormal inflammasome activation was also identified in the endometrium of women who experienced RM. Given inflammasome activation has emerged as common pathophysiology in obesity-related disorder and RM, the investigators wonder whether inflammasome activation occurs in the uterine macrophages of obese women, and result in early reproductive failure.

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Detailed Description

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pending

Conditions

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Obesity Inflammation

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

All women have conceived naturally without the aid of assisted reproductive technologies

Exclusion Criteria

N/A
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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National Cheng-Kung University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pao-Lin Kuo, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Obstetrics and Gynecology, National Cheng Kung University Hospital

Locations

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National Cheng-Kung University Hospital

Tainan City, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Pao-Lin Kuo, MD

Role: CONTACT

[email protected]
886-6-2353535 ext. 5262

PL Kuo, MD

Role: CONTACT

[email protected]
886-6-2353535 ext. 5262

Facility Contacts

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Pao-Lin Kuo, MD

Role: primary

[email protected]
886-6-2353535 ext. 5262

Other Identifiers

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A-ER-105-481

Identifier Type: -

Identifier Source: org_study_id

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