Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
82 participants
OBSERVATIONAL
2013-01-31
2014-02-28
Brief Summary
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Detailed Description
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The fetal origins of adult disease hypothesis suggests that risk factors from intrauterine environmental exposures affect the fetus' development during sensitive periods, and increases the risk of specific diseases in adult life. Our aim is to understand factors that predispose fetuses to fetal overgrowth in utero, especially in women with obesity. The objective of the study is to identify miRNA which are differentially expressed in the placenta and cord blood of pregnancies that are affected by fetal macrosomia to determine factors that may predispose fetuses to fetal overgrowth.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Obese mother/ Macrosomic baby
Obese mother that delivers a macrosomic neonate to understand the effects neonatal exposure to maternal obesity.
Neonatal exposure to maternal obesity
Obese mother/ normal weight baby
Obese mother that delivers a normal weight neonate to understand effects neonatal exposure to maternal obesity.
Neonatal exposure to maternal obesity
Normal weight mother/ Macrosomic baby
Normal weight mother that delivers a macrosomic neonate
No interventions assigned to this group
Normal weight mother/ Normal weight baby
Normal weight mother who delivered a normal weight neonate
No interventions assigned to this group
Interventions
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Neonatal exposure to maternal obesity
Eligibility Criteria
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Inclusion Criteria
* prenatal care \& delivery at the Hospital of the University of Pennsylvania system
* Normal glucose tolerance test results (less than 120 mg/dl)
Exclusion Criteria
* under 18 years old, or over 45 years old
* chronic hypertension
* preeclampsia
* chronic steroid use
* diabetes
* major fetal anomaly
* connective tissue disorder requiring medication
* active HIV
* Hepatitis C
18 Years
45 Years
FEMALE
No
Sponsors
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University of Pennsylvania
OTHER
Responsible Party
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Celeste Durnwald
Assistant Professor, Maternal Fetal Medicine, Department of Obstetrics and Gynecology Director, Penn Perinatal Diabetes Program Director, High Risk Clinic at the Helen O. Dickens Center for Women's Health
Principal Investigators
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Celeste P Durnwald, MD
Role: PRINCIPAL_INVESTIGATOR
University of Pennsylvania
Locations
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Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Countries
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Other Identifiers
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817124
Identifier Type: -
Identifier Source: org_study_id
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