Invasive Coronary Angiography Early in Ischemic Heart Failure

NCT ID: NCT04245605

Last Updated: 2022-08-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

2994 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-04-01

Study Completion Date

2021-09-30

Brief Summary

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To compare the outcomes of patients with acute heart failure who undergo early coronary angiography vs. usual care

Detailed Description

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Conditions

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Acute Heart Failure

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Early angiography

Patients admitted to hospital with acute heart failure undergoing coronary angiography within 14 days of hospital admission

Coronary angiography

Intervention Type PROCEDURE

Coronary angiogram performed either in hospital or post-discharge, within 14 days after initial hospital presentation with heart failure

Control

Patients admitted to hospital with acute heart failure not undergoing coronary angiography within 14 days

No interventions assigned to this group

Interventions

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Coronary angiography

Coronary angiogram performed either in hospital or post-discharge, within 14 days after initial hospital presentation with heart failure

Intervention Type PROCEDURE

Other Intervention Names

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Diagnostic coronary angiography

Eligibility Criteria

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Exclusion Criteria

* Recent myocardial infarction
* Coronary angiogram or revascularization within previous 3 months before admission
* Nonresidents of Ontario, invalid health card number
* HF diagnosed after admission
* Admission BNP or NT-proBNP not diagnostic of HF
* Died within 14 days of admission
* Palliative within 6 months prior to hospital admission
* Elevated creatinine concentration
* Documented anaphylactic contrast allergy
* Ischemic or hemorrhagic stroke within 3 months prior to admission
* Highest category of Hospital Frailty Risk Score
* Active severe bleeding at time of hospital admission
* Absolute platelet count \< 20
* Metastatic cancer
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Institute for Clinical Evaluative Sciences

OTHER

Sponsor Role lead

Responsible Party

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Douglas Lee

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Douglas Lee, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

ICES

Locations

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University Health Network

Toronto, Ontario, Canada

Site Status

Countries

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Canada

Other Identifiers

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3

Identifier Type: -

Identifier Source: org_study_id

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