Transcranial Direct Current Stimulation and Antisocial Behavior

NCT ID: NCT04204759

Last Updated: 2022-10-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

101 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-11-03

Study Completion Date

2023-12-31

Brief Summary

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The main objective of this study is to investigate the causal relationship between prefrontal cortex activity and antisocial behavior, as well as risk factors for antisocial behavior. Specifically, this study tests the hypothesis that upregulating activity in the prefrontal cortex through a non-invasive form of brain stimulation, transcranial direct current stimulation (tDCS) will reduce antisocial and aggressive behavior. The effects of 3 days of anodal stimulation over the prefrontal cortex are assessed.

Detailed Description

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Conditions

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Aggression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Anodal stimulation

Participants in the active stimulation group will undergo anodal transcranial direct current stimulation (tDCS). tDCS will be delivered by a battery-driven, constant-current stimulator connected to two saline-soaked surface sponge electrodes. An anodal electrode (25cm2) will be placed over the ventromedial prefrontal cortex and one cathodal electrode (35cm2) will be placed over the occipital cortex. Scalp electrodes will be positioned according to the 10-20 EEG international system. A current of 2mA will be applied for 20 minutes and the current will be ramped up and down over 30 seconds at the beginning and end of the stimulation period.

Group Type EXPERIMENTAL

Transcranial direct current stimulation

Intervention Type DEVICE

Non-invasive stimulation will be conducted using a tDCS device (StarStim, Neuroelectrics, Spain).

Sham stimulation

The sham tDCS condition will involve the same placement of the electrodes, current intensity, and ramp-up/down time as the active tDCS condition, but stimulation will only last for 30 seconds.

Group Type SHAM_COMPARATOR

Sham transcranial direct current stimulation

Intervention Type DEVICE

The same device will be used as in the active stimulation group, but stimulation will be terminated after 30 seconds.

Interventions

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Transcranial direct current stimulation

Non-invasive stimulation will be conducted using a tDCS device (StarStim, Neuroelectrics, Spain).

Intervention Type DEVICE

Sham transcranial direct current stimulation

The same device will be used as in the active stimulation group, but stimulation will be terminated after 30 seconds.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Above 18 (with parental consent) or above 21 (without parental consent)
* Able to understand the nature of the study and give informed consent

Exclusion Criteria

* History of or active neurologic, cardiovascular, or psychiatric disease including anxiety disorders (e.g., PTSD, panic attacks, obsessive-compulsive disorder) and mood disorders (e.g., depression)
* Currently consuming anti-convulsant, anti-psychotic, or sedative/hypnotic medications
* Currently consuming anti-depressants
* History of seizures
* Metallic implants on scalp
* Participated in any other non-invasive brain stimulation study in the same day
* Ever had an adverse reaction to tDCS
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nanyang Technological University

OTHER

Sponsor Role lead

Responsible Party

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Olivia Choy

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Olivia Choy, PhD

Role: PRINCIPAL_INVESTIGATOR

Nanyang Technological University

Locations

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Nanyang Technological University

Singapore, , Singapore

Site Status

Countries

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Singapore

Other Identifiers

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IRB-2019-06-072

Identifier Type: -

Identifier Source: org_study_id

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