Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
36 participants
INTERVENTIONAL
2023-01-01
2024-07-22
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
TRIPLE
Study Groups
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sham group
In sham group, placebo stimulation is generated by an electrical stimulator and is noninvasively delivered to the left and right dorsolateral prefrontal cortex through a pair of saline-soaked sponge electrodes (7×5 cm) for 30 minutes.
transcranial direct current stimulation (tDCS) sham stimulator
Here a sham electrical current is applied directly between electrodes mounted on the head which can can de-or hyperpolarizes resting membrane potential and thereby modulate cortical excitability
tDCS group
In tDCS, direct electrical currents at the intensity of 2 mA are generated by an electrical stimulator and are noninvasively delivered to the left and right dorsolateral prefrontal cortex through a pair of saline-soaked sponge electrodes (7×5 cm) for 30 minutes.
transcranial direct current stimulation (tDCS) active stimulator
In tDCS the electrical current is applied directly between electrodes mounted on the head which can can de-or hyperpolarizes resting membrane potential and thereby modulate cortical excitability
tRNS group
In tRNS, direct electrical currents at the intensity of 2 mA amplitude (offset at 1 mA) and frequency of 100-640 Hz are generated by an electrical stimulator and are noninvasively delivered to the left and right dorsolateral prefrontal cortex through a pair of saline-soaked sponge electrodes (7×5 cm) for 30 minutes.
transcranial random noise stimulation (tRNS)
Here, an alternating electrical current is applied at a mix of frequencies it is called transcranial random noise stimulation (tRNS), which can be delivered in low (between 0.1-100 Hz) or high (between 101-640 Hz) frequency stimulation
Interventions
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transcranial direct current stimulation (tDCS) active stimulator
In tDCS the electrical current is applied directly between electrodes mounted on the head which can can de-or hyperpolarizes resting membrane potential and thereby modulate cortical excitability
transcranial random noise stimulation (tRNS)
Here, an alternating electrical current is applied at a mix of frequencies it is called transcranial random noise stimulation (tRNS), which can be delivered in low (between 0.1-100 Hz) or high (between 101-640 Hz) frequency stimulation
transcranial direct current stimulation (tDCS) sham stimulator
Here a sham electrical current is applied directly between electrodes mounted on the head which can can de-or hyperpolarizes resting membrane potential and thereby modulate cortical excitability
Eligibility Criteria
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Inclusion Criteria
* Being 18-50 years old (male and female)
* If female, negative urine pregnancy test
* feasibility for tDCS/tRNS interventions according to safety guidelines
* stable medication regime, especially for classical neuroleptics and all central nervous system activating medications, if taken, 4-6 weeks before the experiment
* fluency in the native language
* right-handed
* Required written informed consent signed by patients' guardian
Exclusion Criteria
* alcohol or substance dependence
* comorbid bipolar disorder and mood disorder
* history of seizure
* history of neurological disorder
* history of head injury
* Presence of ferromagnetic objects in the body that are contraindicated for brain stimulation of the head (pacemakers or other implanted electrical devices, brain stimulators, some types of dental implants, aneurysm clips, metallic prostheses, permanent eyeliner, implanted delivery pump, or shrapnel fragments)
18 Years
50 Years
ALL
No
Sponsors
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Leibniz Research Centre for Working Environment and Human Factors
OTHER
Payame Noor University
UNKNOWN
The National Brain Mapping Laboratory (NBML)
OTHER
Responsible Party
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Mohammad Ali Salehinejad
Principal Investigator
Locations
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Payame Noor University, Tehran Branch
Tehran, , Iran
Zanjan University
Zanjān, , Iran
Countries
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Other Identifiers
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ifado-PNU
Identifier Type: -
Identifier Source: org_study_id