RedStroke - Reducing Europe's Stroke Incidence

NCT ID: NCT04108884

Last Updated: 2024-05-17

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

1019 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-22

Study Completion Date

2024-01-18

Brief Summary

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In the RedStroke study, the effect of a smartphone application in detecting Atrial Fibrillation (AF) will be assessed in a double-blind randomised controlled multicenter trial. Outpatients with an elevated risk for atrial fibrillation will be randomized to an intervention arm (app group) and to a standard-of-care arm (control group). Both groups will have the app installed on their private smartphones and will be asked to perform a predefined measurement protocol. All patients will continue their prior therapy with their general practitioner and obtain every medical treatment indicated. This study will not cause any restrictions on the usual treatment of the study patients.

The only difference between the two groups will be, that patients in the app group will be informed by their local PI, if the recordings of the app indicate AF (and obtain a 14 day Holter ECG for AF verification), whereas the patients in the "usual care" group will obtain the read out of the app at the end of the study.

Detailed Description

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Conditions

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Atrial Fibrillation

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

In this study, the effect of a smartphone application in detecting AF will be assessed in a double-blind randomised controlled trial. Patients will be randomized to an intervention arm (app group) and to a standard-of-care arm (control group). Both groups will have the app installed on their private smartphones and will be asked to perform a predefined measurement protocol. The only difference between the two groups will be, that patients in the "app" group will be informed by their local PI, if the recordings of the app indicate AF, whereas the patients in the "usual care" group will obtain the read out of the app at the end of the study (6 months after inclusion).
Primary Study Purpose

SCREENING

Blinding Strategy

TRIPLE

Participants Caregivers Investigators
Patients and study team will remain blind to the assigned groups until the end of the trial. Only in case of a positive app finding, patients and site team will be unblinded for the remaining time of the trial.

Study Groups

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App Group

In the app group, if an episode of arrhythmia is detected with the app, the local investigator will contact the respective patient to schedule an appointment for a 14 day Holter ECG.

Group Type EXPERIMENTAL

App measurement

Intervention Type DEVICE

App measurement twice a day in the first two weeks after enrollment and twice a week (on different days) from the third week onward and whenever patients feel palpitations

14 day Holter ECG

Intervention Type DEVICE

14 day moblie patch Holter ECG for AF confirmation

Standard Care Group

The control group will perform the same measurements as the intervention group, with the only difference that a cumulated Portable Document Format (PDF) report is provided after 6 months instead of the immediate feedback in the app group.

Group Type OTHER

App measurement

Intervention Type DEVICE

App measurement twice a day in the first two weeks after enrollment and twice a week (on different days) from the third week onward and whenever patients feel palpitations

Interventions

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App measurement

App measurement twice a day in the first two weeks after enrollment and twice a week (on different days) from the third week onward and whenever patients feel palpitations

Intervention Type DEVICE

14 day Holter ECG

14 day moblie patch Holter ECG for AF confirmation

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* written informed consent
* CHA2DS2-VASc score of 3 and above, if patients are aged under 65 years
* CHA2DS2-VASc score of 2 and above, if patients are aged 65 years or older

Exclusion Criteria

* history of Atrial Fibrillation
* current anticoagulation treatment,
* cardiac implanted electronic device (ICD or/and PM)
* app cannot be installed due to technical problems (smartphone type, reduced smartphone storage capacity, other)
* inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
* enrollment of the investigator, his/her family members, employees and other dependent persons
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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European Union

OTHER

Sponsor Role collaborator

Preventicus GmbH

INDUSTRY

Sponsor Role collaborator

University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Jens Eckstein, MD, PhD

Role: STUDY_DIRECTOR

University Hospital, Basel, Switzerland

Locations

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University Medicine Greifswald

Greifswald, Mecklenburg-Vorpommern, Germany

Site Status

Ambulantes Herz-Kreislauf-Zentrum

Pasewalk, , Germany

Site Status

Asklepeion Hospital

Athens, Attica, Greece

Site Status

Semmelweis University - Heart and Vascular Center

Budapest, , Hungary

Site Status

University Maastricht Polikliniek Hart+Vaat Centrum

Maastricht, Limburg, Netherlands

Site Status

Jagiellonian University Medical College

Krakow, Lesser Poland Voivodeship, Poland

Site Status

Universitiy Hospital Basel

Basel, Canton of Basel-City, Switzerland

Site Status

Countries

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Germany Greece Hungary Netherlands Poland Switzerland

Other Identifiers

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2019-00908

Identifier Type: -

Identifier Source: org_study_id

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