Systematic NT-proBNP and ECG Screening for Atrial Fibrillation Among 75 Year Old Subjects in the Region of Stockholm, Sweden - STROKESTOP II

NCT ID: NCT02743416

Last Updated: 2020-11-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

6868 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-04-30

Study Completion Date

2023-04-30

Brief Summary

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STROKESTOP II will study if the biomarker NT-proBNP together with single-lead ECG can be used as a primary population screening tool for silent atrial fibrillation, and builds on previous results from the STROKESTOP study.

Detailed Description

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Conditions

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Atrial Fibrillation Stroke

Keywords

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Screening Stroke prevention Cost effectiveness

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ECG screening

Will be screened for AF using only one-stop protocol

ECG screening (Zenicor-ECG) for atrial fibrillation

Intervention Type OTHER

Determination of the biomarker NT-proBNP together with single-lead ECG screening for silent atrial fibrillation.

Control group

as per regular standard as of today

No interventions assigned to this group

Interventions

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ECG screening (Zenicor-ECG) for atrial fibrillation

Determination of the biomarker NT-proBNP together with single-lead ECG screening for silent atrial fibrillation.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Individuals born 1940 and 1941 residing in Stockholm at the time of inclusion
Minimum Eligible Age

75 Years

Maximum Eligible Age

76 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Roche Diagnostics GmbH

INDUSTRY

Sponsor Role collaborator

Karolinska University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Professor Mårten Rosenqvist

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mårten Rosenqvist, MD

Role: PRINCIPAL_INVESTIGATOR

Karolinska Institutet

Locations

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Karolinska Trial Alliance, KTA Prim

Stockholm, , Sweden

Site Status

Countries

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Sweden

References

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Kemp Gudmundsdottir K, Svennberg E, Friberg L, Hygrell T, Frykman V, Al-Khalili F, Hijazi Z, Rosenqvist M, Engdahl J. Randomized Invitation to Systematic NT-proBNP and ECG Screening in 75-Year-Olds to Detect Atrial Fibrillation: STROKESTOP II. Circulation. 2024 Dec 3;150(23):1837-1846. doi: 10.1161/CIRCULATIONAHA.124.071176. Epub 2024 Sep 1.

Reference Type DERIVED
PMID: 39217615 (View on PubMed)

Fredriksson T, Gudmundsdottir KK, Frykman V, Friberg L, Al-Khalili F, Engdahl J, Svennberg E. Brief episodes of rapid irregular atrial activity (micro-AF) are a risk marker for atrial fibrillation: a prospective cohort study. BMC Cardiovasc Disord. 2020 Apr 10;20(1):167. doi: 10.1186/s12872-020-01453-w.

Reference Type DERIVED
PMID: 32276611 (View on PubMed)

Other Identifiers

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STROKESTOP II

Identifier Type: -

Identifier Source: org_study_id