Early Detection of Atrial Fibrillation Using Mobile Technology in Cryptogenic Stroke Patients

NCT ID: NCT05006105

Last Updated: 2022-09-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

225 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-12

Study Completion Date

2025-02-28

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The purpose of this study is to demonstrate the added value of mobile health (mHealth) to detect atrial fibrillation (AF) early in the care path of cryptogenic stroke and transient ischemic attack (TIA) patients.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

The use of photoplethysmography (PPG)-based mHealth (with smartphone and smartwatch) is compared to the guideline-recommended insertable loop recorders (ILR) in the detection of AF in cryptogenic stroke or TIA patients.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Cryptogenic Stroke Atrial Fibrillation

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Group 1 uses PPG-based mHealth with a smartphone; two times a day, a spot-check measurement is taken; and in case of symptoms, additional measurements can be taken.

Group 2 uses PPG-based mHealth with a smartwatch, this results in semi-continuous measurements that are performed automatically.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Participants Caregivers
The participant and care provider are not blinded for which mHealth method is used (smartphone or smartwatch), but are blinded for the mHealth results (i.e., AF detection) during the monitoring period with the mHealth application.

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

PPG-based mHealth on smartphone

Participants used PPG-based mHealth on a smartphone for 6 months. Participants were asked to perform two spot-check measurements and additional measurements in case of symptoms. The use of PPG-based mHealth on a smartphone was initiated on the day of insertable loop recorder insertion.

Group Type EXPERIMENTAL

seven-day ECG Holter

Intervention Type DEVICE

Participants receive a seven-day ECG Holter after hospital discharge.

24-hour blood pressure monitor

Intervention Type DEVICE

Participants receive a 24-hour blood pressure monitor, approximately four weeks after hospital discharge.

Questionnaire: vision of mHealth

Intervention Type OTHER

Participants receive a questionnaire concerning their vision of mHealth, approximately four weeks after hospital discharge.

Questionnaire: user experience & feeling of safety

Intervention Type OTHER

Participants receive a questionnaire concerning their user experience and feeling of safety of using mHealth, after using mHealth for six months.

Insertable loop recorder

Intervention Type DEVICE

Participants receive an insertable loop recorder, approximately six weeks after hospital discharge.

PPG-based mHealth on smartwatch

Participants used PPG-based mHealth on a smartwatch for 6 months. Participants were asked to wear the smartwatch continuously (except during battery charging). The use of PPG-based mHealth on a smartwatch was initiated on the day of insertable loop recorder insertion.

Group Type EXPERIMENTAL

seven-day ECG Holter

Intervention Type DEVICE

Participants receive a seven-day ECG Holter after hospital discharge.

24-hour blood pressure monitor

Intervention Type DEVICE

Participants receive a 24-hour blood pressure monitor, approximately four weeks after hospital discharge.

Questionnaire: vision of mHealth

Intervention Type OTHER

Participants receive a questionnaire concerning their vision of mHealth, approximately four weeks after hospital discharge.

Questionnaire: user experience & feeling of safety

Intervention Type OTHER

Participants receive a questionnaire concerning their user experience and feeling of safety of using mHealth, after using mHealth for six months.

Insertable loop recorder

Intervention Type DEVICE

Participants receive an insertable loop recorder, approximately six weeks after hospital discharge.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

seven-day ECG Holter

Participants receive a seven-day ECG Holter after hospital discharge.

Intervention Type DEVICE

24-hour blood pressure monitor

Participants receive a 24-hour blood pressure monitor, approximately four weeks after hospital discharge.

Intervention Type DEVICE

Questionnaire: vision of mHealth

Participants receive a questionnaire concerning their vision of mHealth, approximately four weeks after hospital discharge.

Intervention Type OTHER

Questionnaire: user experience & feeling of safety

Participants receive a questionnaire concerning their user experience and feeling of safety of using mHealth, after using mHealth for six months.

Intervention Type OTHER

Insertable loop recorder

Participants receive an insertable loop recorder, approximately six weeks after hospital discharge.

Intervention Type DEVICE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Diagnosis of cryptogenic ischemic stroke or TIA
* The patient or its legal representative is willing to sign the informed consent

Exclusion Criteria

* History of AF or atrial flutter
* Life expectancy of less than one year
* Not qualified for ILR insertion
* Indication or contraindication for permanent oral anticoagulants (OAC) at enrolment
* Untreated hyperthyroidism
* Myocardial infarction or coronary bypass grafting less than one month before the stroke onset
* Presence of patent foramen ovale (PFO) and it is or was an indication to start OAC according to the European Stroke Organization guidelines
* Inclusion in another clinical trial that will affect the objectives of this study
* Not able to understand the Dutch language
* Patient or partner not in possession of a smartphone
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Hasselt University

OTHER

Sponsor Role collaborator

Jessa Hospital

OTHER

Sponsor Role collaborator

Ziekenhuis Oost-Limburg

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

David Verhaert, MD

Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Ziekenhuist Oost-Limburg

Genk, Limburg, Belgium

Site Status RECRUITING

Jessa Hospital

Hasselt, Limburg, Belgium

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Belgium

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

David Verhaert, Dr.

Role: CONTACT

+3289 32 70 91

Femke Wouters

Role: CONTACT

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

David Verhaert, Dr.

Role: primary

Femke Wouters, MSc

Role: backup

Thomas Phlips, Dr.

Role: primary

Femke Wouters, MSc

Role: backup

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

CTU2019106

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

Connected Cardiology to Control Cardiac Rythm
NCT06091514 NOT_YET_RECRUITING NA