Timed Exercise Study

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

67 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-06-27

Study Completion Date

2019-03-09

Brief Summary

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The purpose of this study was to investigate the effect of timed exercise on human circadian rhythms. Subjects were randomized to 5 days of morning or evening treadmill exercise. A measure of internal circadian timing, or phase, was measured at baseline and following the exercise intervention. Change in circadian phase was compared between the morning and evening group.

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Detailed Description

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This study investigated the effect of morning versus evening exercise on internal circadian timing, or phase. Young, sedentary subjects were recruited for this study. Baseline measures included anthropometric, body composition, cardiorespiratory fitness, chronotype, and circadian phase. Subjects were randomized to 5 consecutive days of morning or evening exercise. Thirty minutes of exercise was performed at the designated time and intensity was maintained at a heart rate corresponding with 70% peak VO2. The measure of circadian phase was salivary dim light melatonin onset, indicated by the time when saliva melatonin concentration exceeded 4pg/ml. Post-exercise circadian phase was measured the evening following the last day of exercise. Changes in circadian phase were compared between morning and evening groups.

Conditions

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Circadian Timing - Exercise

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Morning Exercise Group

Participants perform moderate exercise in the morning.

Group Type EXPERIMENTAL

Morning Exercise

Intervention Type OTHER

moderate intensity exercise (70% VO2 max) each morning for 5 days

Evening Exercise Group

Participants perform moderate exercise in the evening.

Group Type EXPERIMENTAL

Evening Exercise

Intervention Type OTHER

moderate intensity exercise (70% VO2 max) each evening for 5 days

Interventions

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Morning Exercise

moderate intensity exercise (70% VO2 max) each morning for 5 days

Intervention Type OTHER

Evening Exercise

moderate intensity exercise (70% VO2 max) each evening for 5 days

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* BMI 18.5-40.0
* sedentary; \<=2 hrs structured exercise weekly
* medication free (other than birth control)

Exclusion Criteria

* diagnosed conditions that would contraindicate safe participation in physical activity
* diagnosed psychiatric conditions
* night or rotating shift work 1-year prior to study
* travel across time zones within previous 4 weeks
* having children \<2 years of age
* smoking

Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes