Effect of Exercise on Premature Ejaculation

NCT ID: NCT02984592

Last Updated: 2017-02-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-11-30

Study Completion Date

2017-01-31

Brief Summary

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Premature ejaculation (PE) is one of the prevalent disorders in men; its leading sequel such as lack of self-confidence, anxiety, depression and unsatisfactory intercourse in men and their partners. The current study was aimed to evaluate the relationship between ejaculation and physical activity.

Detailed Description

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Premature ejaculation (PE) is the most frequent sexual dysfunction in males, and its prevalence has been reported as 21-33%. Currently, there are no universal criteria for the diagnosis, or treatment strategies or approaches for PE. Lack of observational studies directed to PE makes comprehension of this sexual dysfunction difficult. The common point for definition of PE is a short duration between penetration and ejaculation, little or no control on voluntary control of ejaculation, and annoying character and negative effect of this condition on the individual. There are various treatment methods since ejaculation physiology and neuroanatomy is not yet clearly demonstrated. According to neurobiological hypothesis of Waldinger, a dysfunction in the serotonin pathway of the central system such as serotonin-2C hyposensitivity and/or serotonin-1A receptor hypersensitivity is a possible cause of lifelong PE. These experimental animal models showed that serotonergic activity at hypothalamic level inhibited ejaculation reflex. Based on this physiological effect, selective serotonin reuptake inhibitors (SSRI), and serotonin agonists increase intravaginal ejaculation latency time (IELT). A number of studies showed that exercise increased the functional effect of serotonin in the human brain.

The effects of physical activity level on human health have attracted interest worldwide. Lack of physical activity forms the basis of various health problems, however regular physical act contributes prevention and treatment of a number of disorders.

In current study, investigators will compare the ejaculation control, IELT, and prevalence of PE between sportsmen that have regular physical activity, and the individuals with a sedentary lifestyle.

Conditions

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Premature Ejaculation

Study Design

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Observational Model Type

COHORT

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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Group 1

The participants in group 1 will state that they participate regular exercise programs in the previous 6 months

physical exercise

Intervention Type BEHAVIORAL

regular exercise programs in the previous 6 months.

Group 2

The participants in group 2 will state that they do not perform any regular exercise in previous 6 months.

No interventions assigned to this group

Interventions

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physical exercise

regular exercise programs in the previous 6 months.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* 18-45-year-old
* sexually active
* heterosexual,without erectile dysfunction
* sexual partner for at least six months, and sexual intercourse at least twice a week

Exclusion Criteria

* chronic systemic disorders (such as diabetes or hypertension)
* use of narcotic/hypnotic drugs or stimulants
* anabolic steroids
* selective serotonin receptors inhibitors
* previous diagnosis and treatment for PE
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Ankara Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Muhammet Fatih Kilinc

M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Ankara Training and Research Hospital

Ankara, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Pastore AL, Palleschi G, Leto A, Pacini L, Iori F, Leonardo C, Carbone A. A prospective randomized study to compare pelvic floor rehabilitation and dapoxetine for treatment of lifelong premature ejaculation. Int J Androl. 2012 Aug;35(4):528-33. doi: 10.1111/j.1365-2605.2011.01243.x. Epub 2012 Feb 9.

Reference Type RESULT
PMID: 22320846 (View on PubMed)

Pastore AL, Palleschi G, Fuschi A, Maggioni C, Rago R, Zucchi A, Costantini E, Carbone A. Pelvic floor muscle rehabilitation for patients with lifelong premature ejaculation: a novel therapeutic approach. Ther Adv Urol. 2014 Jun;6(3):83-8. doi: 10.1177/1756287214523329.

Reference Type RESULT
PMID: 24883105 (View on PubMed)

Other Identifiers

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5006

Identifier Type: -

Identifier Source: org_study_id

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