Study Results
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Basic Information
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COMPLETED
NA
16 participants
INTERVENTIONAL
2015-06-30
2016-03-31
Brief Summary
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Objective. To determine if 7 weeks of exercise training can limit cardiovascular dysfunction induced by total sleep deprivation (TSD) in healthy young men.
Methods: 16 subjects will be examined during 40-h TSD, both before and after 7 weeks of interval exercise training. Vasodilatation induced by ACh, insulin and heat (42°C) as well as pulse wave velocity (PWV), blood pressure and heart rate (HR) will be assessed at baseline, during TSD, and after one night of sleep recovery. Biomarkers of endothelial activation, inflammation, and hormones will bemeasured from morning blood samples at 07:00
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
PREVENTION
NONE
Study Groups
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Exercise training
7 weeks of exercise training
Sleep deprivation
40 hours of continuous wakefullness
Control
Sedentary group
Sleep deprivation
40 hours of continuous wakefullness
Interventions
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Sleep deprivation
40 hours of continuous wakefullness
Eligibility Criteria
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Inclusion Criteria
* Men
* 18 - 35 yrs
Exclusion Criteria
* Body mass index (BMI) greater than 30 kg/m²,
* Taking medication.
* Excessive daytime somnolence (Epworth Sleepiness Scale \>9)
* Sleep complaints (Pittsburgh Sleep Quality Index \>5)
* Inability to be considered as an intermediate chronotype on the Horne and Ostberg questionnaire (score \<31 or \>69)
* Traines subject (Ricci Gagnon questionnaire \>35)
18 Years
35 Years
MALE
Yes
Sponsors
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Cetre du sommeil et de la vigilance, APHP
UNKNOWN
Institut de Recherche Biomedicale des Armees
OTHER_GOV
Responsible Party
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References
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Sauvet F, Drogou C, Bougard C, Arnal PJ, Dispersyn G, Bourrilhon C, Rabat A, Van Beers P, Gomez-Merino D, Faraut B, Leger D, Chennaoui M. Vascular response to 1 week of sleep restriction in healthy subjects. A metabolic response? Int J Cardiol. 2015;190:246-55. doi: 10.1016/j.ijcard.2015.04.119. Epub 2015 Apr 16.
Arnal PJ, Drogou C, Sauvet F, Regnauld J, Dispersyn G, Faraut B, Millet GY, Leger D, Gomez-Merino D, Chennaoui M. Effect of Sleep Extension on the Subsequent Testosterone, Cortisol and Prolactin Responses to Total Sleep Deprivation and Recovery. J Neuroendocrinol. 2016 Feb;28(2):12346. doi: 10.1111/jne.12346.
Arnal PJ, Sauvet F, Leger D, van Beers P, Bayon V, Bougard C, Rabat A, Millet GY, Chennaoui M. Benefits of Sleep Extension on Sustained Attention and Sleep Pressure Before and During Total Sleep Deprivation and Recovery. Sleep. 2015 Dec 1;38(12):1935-43. doi: 10.5665/sleep.5244.
Sauvet F, Arnal PJ, Tardo-Dino PE, Drogou C, Van Beers P, Bougard C, Rabat A, Dispersyn G, Malgoyre A, Leger D, Gomez-Merino D, Chennaoui M. Protective effects of exercise training on endothelial dysfunction induced by total sleep deprivation in healthy subjects. Int J Cardiol. 2017 Apr 1;232:76-85. doi: 10.1016/j.ijcard.2017.01.049. Epub 2017 Jan 5.
Other Identifiers
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2014_A01103-44
Identifier Type: OTHER
Identifier Source: secondary_id
PDH-1-SMO-2-508
Identifier Type: -
Identifier Source: org_study_id
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