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Effects of Aerobic Training in End Stage Renal Disease Patients

NCT ID: NCT01234688

Last Updated: 2010-11-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

28 participants

Study Classification

INTERVENTIONAL

Study Start Date

2008-06-30

Study Completion Date

2010-06-30

Brief Summary

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The investigators raised the hypothesis that exercise training would be associated with improvement in exercise tolerance and VO2 kinetics in hemodialysis patients.

Detailed Description

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End-stage renal disease (ESRD) is associated with several hemodynamic and peripheral muscle abnormalities which could slow the kinetics of O2 uptake(VO2)and diminished tolerance to incremental exercise. Although previous studies have shown that aerobic training is able to accelerate VO2 kinetics in several disease populations, little is known if these positive findings are also applicable to hemodialysis patients.

Conditions

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Kidney Failure, Chronic

Keywords

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Exercise Tolerance Physical Endurance

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Exercise training

Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.

Group Type EXPERIMENTAL

Exercise training

Intervention Type OTHER

Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.

Control

Patients allocated to the control group remained in regular dialysis treatment during the same timeframe.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Exercise training

Patients included in the exercise group were submitted to intra-dialytic exercise training, 3 times per week for 12 weeks.

Intervention Type OTHER

Other Intervention Names

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Exercise group

Eligibility Criteria

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Inclusion Criteria

The sample included end stage renal disease patients undergoing hemodialysis, three times per week totaling 12h weekly, for at least 6 months in the Nephrology Unit at the University Hospital of the Federal University of Juiz de Fora, State of Minas Gerais, Brazil. No patient had been involved in any kind of exercise training in the preceding 6 months

Exclusion Criteria

* unstable angina;
* uncontrolled arrhythmia;
* uncompensated heart failure;
* uncontrolled hypertension (systolic blood pressure ≥ 200 mmHg and/or diastolic blood pressure ≥ 120 mmHg);
* diabetes mellitus;
* severe respiratory diseases;
* acute infection;
* severe renal osteodystrophy;
* neurological or musculoskeletal disturbances
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Federal University of Juiz de Fora

OTHER

Sponsor Role lead

Responsible Party

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Federal University of Juiz de Fora

Principal Investigators

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Maycon M Reboredo, DSc

Role: PRINCIPAL_INVESTIGATOR

Federal University of Juiz de Fora

Rogério B de Paula, DSc

Role: STUDY_DIRECTOR

Federal University of Juiz de Fora

Locations

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Federal University of Juiz de Fora-Núcleo Interdisciplinar de Estudos e Pesquisas em Nefrologia (NIEPEN)

Juiz de Fora, Minas Gerais, Brazil

Site Status

Countries

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Brazil

References

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Bernier-Jean A, Beruni NA, Bondonno NP, Williams G, Teixeira-Pinto A, Craig JC, Wong G. Exercise training for adults undergoing maintenance dialysis. Cochrane Database Syst Rev. 2022 Jan 12;1(1):CD014653. doi: 10.1002/14651858.CD014653.

Reference Type DERIVED
PMID: 35018639 (View on PubMed)

Reboredo MM, Neder JA, Pinheiro BV, Henrique DM, Lovisi JC, Paula RB. Intra-dialytic training accelerates oxygen uptake kinetics in hemodialysis patients. Eur J Prev Cardiol. 2015 Jul;22(7):912-9. doi: 10.1177/2047487314543079. Epub 2014 Jul 18.

Reference Type DERIVED
PMID: 25038079 (View on PubMed)

Reboredo MM, Neder JA, Pinheiro BV, Henrique DM, Faria RS, Paula RB. Constant work-rate test to assess the effects of intradialytic aerobic training in mildly impaired patients with end-stage renal disease: a randomized controlled trial. Arch Phys Med Rehabil. 2011 Dec;92(12):2018-24. doi: 10.1016/j.apmr.2011.07.190.

Reference Type DERIVED
PMID: 22133251 (View on PubMed)

Other Identifiers

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001

Identifier Type: -

Identifier Source: org_study_id