Relationship Between the VEGF Gene Polymorphism and Cardiometabolic Risk Factors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

400 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-01-01

Study Completion Date

2019-08-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of the study is to determine the relationship between VEGF gene expression, VEGF gene polymorphism and serum leptin concentration in the Polish population in people with excessive body weight. In addition, the aim of the study is to look for relationships between the VEGF gene polymorphism and anthropometric and biochemical factors of cardiovascular risk and endothelial dysfunction such as body weight, waist circumference, serum total cholesterol, LDL, HDL, triglycerides, glucose and the occurrence of cardiovascular diseases in the family of a patient with excessive body weight in the Polish population.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Baseline Physiology Studies in Carriers of Gene Variant X Conferring Major Risk of CVD-prone Metabolic Disorders

NCT01571609

Hyperlipidemia Diabetes Mellitus Metabolic Syndrome +2 more

COMPLETED NA

Impact of Polymorphism on Pulmonary Pressure in Subjects With Pulmonary Hypertension of Different Cause

NCT00893178

Congestive Heart Failure Pulmonary Hypertension

COMPLETED

Genetic Assessment of the Patients With Metabolic Syndrome

NCT01268696

Metabolic Syndrome

UNKNOWN

Identification of Genetic Markers for Cardiopulmonary Diseases (Genotype)

NCT00616369

Cardiovascular Diseases

COMPLETED

Molecular Investigation of Genetic Factors in CArDiovascular Diseases Using an BIOresource of Healthy Volunteers

NCT03038750

Cardiovascular Diseases

TERMINATED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

400 people (250 - study group; 150 control group) were subjected to subjective and objective action. Information on the occurrence of diseases and cardiovascular risk in the participant and his family was collected from research studies. Anthropometric parameters were measured (body weight, height, BMI, waist circumference, neck circumference) as well as blood pressure and pulse measurement. In addition, fasting venous blood was collected and secured. In venous blood currently marked with the following concentration: glucose, required cholesterol, LDL cholesterol, HDL cholesterol and triglycerides. In addition, a method of salting out and protecting DNA was developed from blood.

Furthermore the polymorphisms of VEGF genes (in positions: -2578 and -634) using the HMR (High Resolution Melt) method was determined.

Also VEGF and leptin by ELISA was determined. After obtaining the results of comparative analysis of the correlation between the occurrence of VEGF gene polymorphisms, serum levels of leptin and VEGF, and anthropometric and biochemical parameters of cardiovascular risk.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Polymorphism, Restriction Fragment Length

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

OTHER

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Study group

women and men with excess body mass

gene expression

Intervention Type GENETIC

determination of VEGF gene expression, VEGF gene polymorphism and serum leptin concentration

Control group

women and men with proper body mass

gene expression

Intervention Type GENETIC

determination of VEGF gene expression, VEGF gene polymorphism and serum leptin concentration

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

gene expression

determination of VEGF gene expression, VEGF gene polymorphism and serum leptin concentration

Intervention Type GENETIC

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* informed consent in writing
* stable body mass (+/- 1 kg)
* excessive body mass (BMI ≥ 25 kg/m2- study group)
* proper body mass (BMI \< 25 kg/m2- control group)

Exclusion Criteria

* age \<18 years
* secondary obesity
* pregnancy, lactation
* other conditions that in the opinion of researchers may pose any risk to the patient during the study.

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes