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Association Study of Gene Polymorphisms With Cardiac Performance

NCT ID: NCT00730899

Last Updated: 2008-08-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-05-31

Study Completion Date

2011-06-30

Brief Summary

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The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Detailed Description

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G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Conditions

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Genetic Polymorphism Coronary Artery Disease Hemodynamics

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* clinical diagnosis of coronary artery disease
* patients scheduled for coronary artery bypass grafting

Exclusion Criteria

* emergency operation
* combined vitium
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University Hospital, Essen

OTHER

Sponsor Role lead

Responsible Party

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University Hospital Essen

Principal Investigators

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Jürgen Peters, MD

Role: STUDY_DIRECTOR

University Hospital, Essen

Locations

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University Hospital

Essen, North Rhine-Westphalia, Germany

Site Status RECRUITING

Countries

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Germany

Central Contacts

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Ulrich H Frey, MD

Role: CONTACT

Phone: +49201723

Email: [email protected]

Facility Contacts

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Ulrich H Frey, MD

Role: primary

Other Identifiers

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HOT-001

Identifier Type: -

Identifier Source: org_study_id