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Longitudinal Interaction Between APOA5 -1131T>C and Overweight Accelerates Arterial Stiffness

NCT ID: NCT03367598

Last Updated: 2017-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

503 participants

Study Classification

OBSERVATIONAL

Study Start Date

2008-01-01

Study Completion Date

2013-12-31

Brief Summary

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The aim of this study is to evaluate whether the longitudinal interaction between APOA5 -1131C variants and overweight could accelerate age-related increases in arterial stiffness and circulating triglycerides in healthy subjects.

Detailed Description

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Conditions

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Overweight and Obesity

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Normal weight

nondiabetic and nonobese individuals (18.5 kg/m2 ≤ BMI \< 25 kg/m2, n=349)

rs662799 (APOA5 -1131T>C)

Intervention Type GENETIC

Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism.

Overweight

nondiabetic and nonobese individuals (25 kg/m2 ≤ BMI \< 30 kg/m2, n=154)

rs662799 (APOA5 -1131T>C)

Intervention Type GENETIC

Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism.

Interventions

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rs662799 (APOA5 -1131T>C)

Among the 349 normal-weight individuals, 168 were homozygous (TT) for the T allele, 155 were heterozygous for the C allele (TC) and 26 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism. Among the 154 overweight individuals, 68 were homozygous (TT) for the T allele, 75 were heterozygous for the C allele (TC) and 11 were homozygous (CC) for the C allele of the APOA5 -1131T\>C polymorphism.

Intervention Type GENETIC

Eligibility Criteria

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Inclusion Criteria

* Nondiabetic (fasting serum glucose concentration \< 126 mg/dL)
* Nonobese (BMI ≥ 25 kg/m2)

Exclusion Criteria

* Current and/or past history of cardiovascular disease
* Diabetes mellitus (fasting glucose levels ≥126 mg/dL)
* Abnormal liver or renal function
* Thyroid or pituitary disease
* Pregnancy or lactation
* Regular use of any medication
Minimum Eligible Age

30 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Yonsei University

OTHER

Sponsor Role lead

Responsible Party

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Jong Ho Lee

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Jong Ho Lee, PhD

Role: PRINCIPAL_INVESTIGATOR

Dept. of Food and Nutrition, Colleage of Human Ecology, Yonsei University

Other Identifiers

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PA_fu_APOA5_rs662799

Identifier Type: -

Identifier Source: org_study_id