Genetic Epidemiology--Development of Cardiovascular Risk
NCT ID: NCT00005512
Last Updated: 2016-03-01
Study Results
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Basic Information
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COMPLETED
OBSERVATIONAL
1998-08-31
2002-07-31
Brief Summary
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Detailed Description
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Obesity and hypertension are two of the major risk factors for cardiovascular disease (CVD) and those with obesity have a greater risk of hypertension. In children and adolescents, high body mass index correlates with elevated blood pressure. Genetic factors make a significant contribution to the variation of obesity and hypertension.
DESIGN NARRATIVE:
Anthropometric, cardiovascular, physiologic and physical fitness data were used to investigate a series of critical issues about the etiology, heterogeneity, comorbidity and developmental trajectories of CVD risk factors, including obesity, hypertension and cardiovascular health. Using the two datasets, the main questions of the study were addressed. How do genes and environment act and interact to create covariation between obesity and hypertension, and were the genetic and environmental factors the same at all ages (from childhood to late adolescence and adulthood) in both sexes? Areas of research included the following: causes of individual differences in anthropometric and cardiovascular characteristics, their covariation and developmental change or continuity in adolescence, parent-offspring transmission, prediction of cardiovascular risk, and sex, race and population differences in genetic and environmental contributions on cardiovascular risk factors.
Conditions
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Eligibility Criteria
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Inclusion Criteria
10 Years
18 Years
ALL
No
Sponsors
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National Heart, Lung, and Blood Institute (NHLBI)
NIH
Virginia Commonwealth University
OTHER
Principal Investigators
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Hermine Maes
Role:
Virginia Commonwealth University
References
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Beunen G, Thomis M, Maes HH, Loos R, Malina RM, Claessens AL, Vlietinck R. Genetic variance of adolescent growth in stature. Ann Hum Biol. 2000 Mar-Apr;27(2):173-86. doi: 10.1080/030144600282280.
Sicherer SH, Furlong TJ, Maes HH, Desnick RJ, Sampson HA, Gelb BD. Genetics of peanut allergy: a twin study. J Allergy Clin Immunol. 2000 Jul;106(1 Pt 1):53-6. doi: 10.1067/mai.2000.108105.
Other Identifiers
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5030
Identifier Type: -
Identifier Source: org_study_id
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