Development of a Model-based Working Memory Training and Investigation of Its Comparative Efficacy

NCT ID: NCT04042779

Last Updated: 2020-07-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

131 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-07-02

Study Completion Date

2020-03-13

Brief Summary

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This study is to investigate the efficacy of model-based Working Memory (WM) training using an appropriate control condition. The interventions are a model-based, a single-task and a multiple-task training on WM in order to compare the efficacies of these different training approaches for WM. A sham intervention acts as active control group. Each intervention will be presented on a tablet device.

Detailed Description

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Conditions

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Working Memory

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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model-based WM training

In order to build the model-based WM training, existing tasks used to assess the different component of the Baddeley's model will be reviewed on their findings according to test-retest reliability and construct validity. For each component - phonological loop, visuospatial sketchpad, episodic buffer and central executive - the task with the highest reliability and validity will be chosen and then build the basis for the computerized training program. This procedure results in a model-based, adaptive, computerized training program for WM.

Group Type ACTIVE_COMPARATOR

model-based WM training

Intervention Type OTHER

model-based WM training program: four sessions a week, 45 minutes each; lasting for three weeks

single-task WM training

The basis for the single-task training administered to the second group will be the widely used "dual-n-back training paradigm" suggested by Jaeggi et al. (2008). A complex dual n-back task including a visual and an auditory WM task will be implemented for tablet devices.

Group Type ACTIVE_COMPARATOR

single-task WM training

Intervention Type OTHER

single-task WM training program: four sessions a week, 45 minutes each; lasting for three weeks

multiple-task WM training

Verbal WM tasks - particularly letter span and digit span tasks - and a visuospatial WM task are most commonly used (e.g. Dahlin et al., 2008; Klingberg et al., 2005; Westerberg et al., 2007). Therefore, a multiple-task training including these tasks will be administered to the third group.

Group Type ACTIVE_COMPARATOR

multiple-task WM training

Intervention Type OTHER

multiple-task WM training program: four sessions a week, 45 minutes each; lasting for three weeks

sham intervention

Active control group that as well performs a training, however not based on WM. To exclude the involvement of WM, a motor training will be administered to the control group.

Group Type SHAM_COMPARATOR

sham intervention

Intervention Type OTHER

motor training program: four sessions a week, 45 minutes each; lasting for three weeks

Interventions

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model-based WM training

model-based WM training program: four sessions a week, 45 minutes each; lasting for three weeks

Intervention Type OTHER

single-task WM training

single-task WM training program: four sessions a week, 45 minutes each; lasting for three weeks

Intervention Type OTHER

multiple-task WM training

multiple-task WM training program: four sessions a week, 45 minutes each; lasting for three weeks

Intervention Type OTHER

sham intervention

motor training program: four sessions a week, 45 minutes each; lasting for three weeks

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Informed consent as documented by signature

Exclusion Criteria

* Medical history of neurological or psychiatric disorders
* Any history of substance abuse
* Color vision deficiency
* Inability to used table devices
* Montreal Cognitive Assessment \< 26
Minimum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University Hospital, Basel, Switzerland

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stefano Magon, Dr. phil.

Role: PRINCIPAL_INVESTIGATOR

Department of Neurology, University Hospital Basel

Locations

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Department of Neurology, University Hospital Basel

Basel, , Switzerland

Site Status

Countries

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Switzerland

Other Identifiers

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2018-01226; me19Magon

Identifier Type: -

Identifier Source: org_study_id

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