Peanut Protein Supplementation to Augment Muscle Growth and Improve Markers of Muscle Quality and Health in Older Adults

NCT ID: NCT04015479

Last Updated: 2021-01-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 41 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-09-26
• Study Completion Date: 2020-05-01

Brief Summary

This study will evaluate the adaptations in skeletal muscle that occur in response to 10 weeks of weight training with or without peanut protein supplementation in older adult men and women.

Detailed Description

Aging is associated with declines in muscle mass, physical strength and physical function. Adequate quality protein intake in aging adults is critical to preventing functional decline. Peanuts provide a unique blend of amino acids that can provide several health benefits to aging adults. While supplementing with peanut protein (PP) powder as part of a resistance training program may increase myofibrillar protein synthesis (i.e., the gold standard molecular assessment in deciphering a muscle-building response), and improve skeletal muscle quality and body composition, no study to date has made this determination.

This is a two-phase study using both novel and conventional methods to assess how PP supplementation affects muscle tissue in older individuals who engage in resistance training. These two phases will be conducted as part of a 10-week randomized controlled trial in which men and women aged 50 years and older (n=60), will be stratified by gender and randomized to a resistance training intervention (whole body, two days per week) with PP powder (72g daily; n=15 males, n=15 females) provided during the intervention (immediate group, IG) or after the intervention (wait-list control, WLC, n=15 males, n=15 females). The aims of this study are to determine the acute (deuterium oxide tracer) and chronic (peripheral quantitative computed tomography) effects of PP during resistance training on skeletal muscle myofibrillar protein synthesis rates, changes in skeletal muscle size and quality, changes in whole and appendicular body composition (dual energy x-ray absorptiometry), changes in inflammatory markers and the fecal microbiome.

Conditions

Aging; Sarcopenia

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: DOUBLE

Study Groups

Immediate Intervention Group

Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder (72g/day) will be provided for daily consumption during the study period

Group Type: EXPERIMENTAL

Peanut Protein Powder

Intervention Type: DIETARY_SUPPLEMENT

Peanut protein powder will be provided to participants who will be instructed to consume 72g daily, mixed with water

Full body resistance training

Intervention Type: BEHAVIORAL

Participants will undergo supervised resistance training two times per week (5 exercises, 3 sets of 8-12 repetitions per set)

Wait-list Control Group

Participants will complete 10 weeks of twice-weekly whole body resistance training. Peanut protein powder will be provided after the study period

Group Type: ACTIVE_COMPARATOR

Full body resistance training

Intervention Type: BEHAVIORAL

Participants will undergo supervised resistance training two times per week (5 exercises, 3 sets of 8-12 repetitions per set)

Interventions

Peanut Protein Powder

Peanut protein powder will be provided to participants who will be instructed to consume 72g daily, mixed with water

Intervention Type: DIETARY_SUPPLEMENT

Full body resistance training

Participants will undergo supervised resistance training two times per week (5 exercises, 3 sets of 8-12 repetitions per set)

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• body mass index (body mass/height squared) less than 35 kg/m2
• resting blood pressure averaging less than 140/90 mmHg (with or without medication)

Exclusion Criteria

• known peanut allergy
• actively participating in resistance training for more than 2 days/week
• any known overt cardiovascular or metabolic disease
• metal implants that will interfere with x-ray procedures
• medically necessary radiation exposure in the last six months (except dental x-ray)
• any medical condition that would contradict participating in an exercise program, giving blood or donating a skeletal muscle biopsy (i.e. blood clotting disorder or taking blood thinners)

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 80 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Edward Via Virginia College of Osteopathic Medicine

OTHER

Sponsor Role: collaborator

The Peanut Institute

OTHER

Sponsor Role: collaborator

Auburn University

OTHER

Sponsor Role: lead

Responsible Party

Andrew Fruge

Assistant Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Michael Roberts, PhD

Role: PRINCIPAL_INVESTIGATOR

Auburn University

Locations

Auburn University

Auburn, Alabama, United States

Countries

United States

References

Lamb DA, Moore JH, Smith MA, Vann CG, Osburn SC, Ruple BA, Fox CD, Smith KS, Altonji OM, Power ZM, Cerovsky AE, Ross CO, Cao AT, Goodlett MD, Huggins KW, Fruge AD, Young KC, Roberts MD. The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals. J Int Soc Sports Nutr. 2020 Dec 14;17(1):66. doi: 10.1186/s12970-020-00397-y.

Reference Type: BACKGROUND

PMID: 33317565 (View on PubMed)

Other Identifiers

19-249

Identifier Type: -

Identifier Source: org_study_id