Involvement of the Mediodorsal Nucleus of the Thalamus in Higher Order Cognitive Processes

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-05-14

Study Completion Date

2023-04-30

Brief Summary

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The aim is to expand evidence about the importance of the mediodorsal nucleus of the thalamus as a key node in human higher-order cognitive functions such as learning, decision-making, and adaptive behavior. Thus, the project proposes to assess global cognition along with higher-order cognition integrity via sensitive behavior tasks in patients with well localized lesions (mediodorsal thalamic infarcts) compared with healthy participants.

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Detailed Description

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The recruitment of patients with isolated thalamic lesion after stroke is known to be a challenge that the investigators overcame through the expertise of neurologists within their stroke unit.

First, they will describe the cognitive profile consecutive to a lesion of the thalamus, assessed with standardized neuropsychological tests.

Second, and more specifically, they will study performances at experimental tasks focusing on higher-order cognition (decision-making, updating, interference managing, multitasking).

They will use the automatic localization method already performed : the lesions will be manually segmented from T1 morphologic sequences, and then normalized in a template. Finally a numerical atlas of thalamus will be applied on the lesions, determining the injured substructure and the lesion volume.

Besides, this method will be compared with new high resolution thalamus-centered anatomical sequences allowing direct and individual identification of the involved thalamic nucleus.

Conditions

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Thalamic Infarction

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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patient with first thalamic infarct

Patient with first thalamic infarct, they will undergo detailed neuropsychological assessment of memory, language, executive functions and mood along detailed neuroimaging including high-resolution imaging of the thalamus, DTI and resting state fMRI.

Group Type OTHER

neuroimaging

Intervention Type OTHER

neuroimaging including high-resolution imaging of the thalamus, DTI and resting state fMRI

Neuropsychological assessment

Intervention Type OTHER

neuropsychological assessment of memory, language, executive functions and mood

healthy subject matched with control

Healthy subject matched with control, they will undergo detailed neuropsychological assessment of memory, language, executive functions and mood along detailed neuroimaging including high-resolution imaging of the thalamus, DTI and resting state fMRI.

Group Type OTHER

neuroimaging

Intervention Type OTHER

neuroimaging including high-resolution imaging of the thalamus, DTI and resting state fMRI

Neuropsychological assessment

Intervention Type OTHER

neuropsychological assessment of memory, language, executive functions and mood

Interventions

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neuroimaging

neuroimaging including high-resolution imaging of the thalamus, DTI and resting state fMRI

Intervention Type OTHER

Neuropsychological assessment

neuropsychological assessment of memory, language, executive functions and mood

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* French as their mother tongue
* Absence of cognitive deterioration before the stroke.
* Visual, auditory (equipment authorized) and oral or written skills sufficient for the proper assessment using neuropsychological tests.
* First infarct affecting the thalamus.
* At least seven years' schooling from primary school
* Signed informed consent
* Chronic lesion (\> 3 months)

* French as their mother tongue
* Absence of cognitive complain
* Visual, auditory (equipment authorized) and oral or written skills sufficient for the proper assessment using neuropsychological tests.
* At least seven years of school from primary school
* Signed informed consent

Exclusion Criteria

* Neurological deficit or significant residual disability at inclusion.
* Aphasia, agnosia, apraxia or severe neglect, as demonstrated by clinical examination and neuropsychological tests.
* Subjects with a contraindication to MRI.
* General, neurological or psychiatric progressive disease.

* Subjects with a contraindication to MRI.
* General, neurological or psychiatric progressive disease.

Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes