Attentional Control

NCT ID: NCT03872999

Last Updated: 2022-01-11

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 76 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2019-07-05
• Study Completion Date: 2021-06-21

Brief Summary

The project is dedicated to understanding the integration within the brain of signals of different natures that contribute to attentional control. The investigator will make use of standardized experimental displays involving the discrimination of a target (tilted-bar) presented together with 3 distractor items, with one stimulus in each visual quadrant. Across three fMRI experiments in healthy participants, the investigator will manipulate different types of signals that will guide the subject's attention towards one of the four quadrants: Exp 1 - task instruction & item salience; Exp 2 - probabilistic target location; Exp 3 - probabilistic reward. The investigator expects that irrespective of the nature of the control signal, activity in dorsal parietal cortex will index the currently relevant/attended location. Moreover, The investigator expects that upon changes of the most relevant location, one will observe activation of the ventral parietal cortex, plus increased inter-regional connectivity between ventral and dorsal parietal regions - again irrespective of the nature of the attention guiding signals.

Conditions

Attention Control; Healthy Volunteers

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: BASIC_SCIENCE
• Blinding Strategy: NONE

Study Groups

Attentional Control

Visuo-spatial attentional tasks with simple stimuli during functional magnetic resonance imaging (fMRI) scanning.

Group Type: EXPERIMENTAL

Functional brain imaging without any contrast agent

Intervention Type: OTHER

During the functional magnetic resonance imaging (fMRI) protocol, the subject will perform the attentional task while whole-brain activity will be recorded using Echo Planar Imaging (EPI) that measures the Blood Oxygen Level Dependent (BOLD) signal (2x2x2 isotropic voxels, Echo Time (ET) = 30 ms, Repetition Time (RT) = 2.5 sec). The functional session will be subdivided into several parts ("Runs", duration: 10-15 min). Together with the functional data, the protocol will include a structural scan (T1 weighted, 1x1x1 mm voxels; duration 5-7 min) and a field mapping sequence (duration: 1 min).

Interventions

Functional brain imaging without any contrast agent

During the functional magnetic resonance imaging (fMRI) protocol, the subject will perform the attentional task while whole-brain activity will be recorded using Echo Planar Imaging (EPI) that measures the Blood Oxygen Level Dependent (BOLD) signal (2x2x2 isotropic voxels, Echo Time (ET) = 30 ms, Repetition Time (RT) = 2.5 sec). The functional session will be subdivided into several parts ("Runs", duration: 10-15 min). Together with the functional data, the protocol will include a structural scan (T1 weighted, 1x1x1 mm voxels; duration 5-7 min) and a field mapping sequence (duration: 1 min).

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Be 18 to 40 years old

Exclusion Criteria

• Previous neurologic or psychiatric disease.
• Cognitive deficits restricting understanding of the tasks.
• Pregnant or breath-feeding women.
• Persons under guardianship, curator or any other administrative or judicial measure of deprivation of rights or liberty.
• Subjects currently participating in other study.

• Neurologic, cardiac electrostimulation or defibrillator.
• Cardiac prostheses
• Intracranial clips or clamps
• Cerebrospinal fluid disorders
• Metal particles in the eyes
• Metal dental or articular prostheses
• Diffusion pomp or other infusion system
• Claustrophobia
• Head tattoo, make-up, hair gel
• Have any copper intrauterine device

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Hospices Civils de Lyon

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Emiliano Macaluso, Prof.

Role: PRINCIPAL_INVESTIGATOR

INSERM U1028 - Equipe ImpAct CRNL

Locations

Inserm U1028 Equipe Impact

Bron, , France

Countries

France

Other Identifiers

2019-A00713-54

Identifier Type: OTHER

Identifier Source: secondary_id

69HCL19_0127

Identifier Type: -

Identifier Source: org_study_id