Cartography of Functional and Epileptic Cerebral Areas by Functional MRI and Electroencephalography in Epileptic Patients Before and After Surgery

NCT ID: NCT03102957

Last Updated: 2017-04-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2009-06-17

Study Completion Date

2016-08-31

Brief Summary

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Exploring the reorganization (plasticity) of neuroanatomic networks associated with language and memory in patients with left (or dominant hemisphere) temporal lobe epilepsy using functional MRI (fMRI)

Detailed Description

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The purpose of this study is to explore the reorganization of neuroanatomic networks associated with language and memory in adult patients with temporal lobe epilepsy (ELT). By using functional MRI, patients will be examined before and after surgery. Cerebral plasticity, defined in terms of intrinsic variables such as the topography of the activated regions, will be explored according to some extrinsic factors such as the age at onset of crises (before or after 5-6 years), whether or not Hippocampal sclerosis, hemispheric predominance of language (left or right).

Conditions

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Epilepsy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

2 arms : epileptic patient and healthy volonteers
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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epileptic patients

2 functional MRI (pre and post resective surgery) with memory and language tasks

Group Type EXPERIMENTAL

functional MRI

Intervention Type OTHER

Healthy volunteers

1 functional MRI with memory and language tasks

Group Type OTHER

functional MRI

Intervention Type OTHER

Interventions

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functional MRI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* epileptic patients
* medical exam before inclusion
* social security affiliation
* Pharmaco-resistant epilepsy

Exclusion Criteria

* MRI contraindication
* pregnant women
* breastfeeding mothers
* person under tutorship
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Laboratoire de Psychologie et NeuroCognition

OTHER

Sponsor Role collaborator

University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alexandre KRAINIK, PhD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Grenoble

Other Identifiers

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38RC09.21

Identifier Type: -

Identifier Source: org_study_id

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