Single Neurons Responses During Visual Recognition in Epileptic Patients
NCT ID: NCT02877576
Last Updated: 2021-04-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
20 participants
INTERVENTIONAL
2016-05-31
2023-05-31
Brief Summary
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Secondary purpose is to evaluate specific capacities of detection of known faces of individual neurons by comparison with their capacity of detection of unknown faces in medial temporal lobe and ventral temporal cortex in epileptic patients.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Epileptic patient
micro-electrode recordings interventions: Implantation of mixed intracerebral electrodes Face detection Face individualization
Implantation of mixed intracerebral electrodes
5 macro electrodes with micro electrodes are implanted in internal temporal structures (amygdala, anterior and posterior hippocampus, rhinal cortex, posterior para-hippocampal gyrus).
Each electrode has 8 microcontacts, each recording the activity of 0 to 3 neurons (activity of 0 to 120 neurons/patient).
Face detection
Visualization of images of 60 unknown faces and 60 objects that are not faces (object, house, scene, animal, plant, word, letter…). Each image is showed for 500 ms and separated from following image by black screen of 1500 ms. In order to keep patient attention on image, patient will be asked to push a button at color change of fixation cross in the centre of image.
Face individualization
Visualization of images of celebrities (persons known by patient), showed randomly. Each image is showed for 500 ms and separated from following image by black screen of 1500 ms. In order to keep patient attention on image, patient will be asked to push a button at color change of fixation cross in the centre of image.
Several celebrities are showed, with for each the presentation of 60 images different from that celebrity. 1 to 3 celebrities are showed (60 to 180 total images).
Interventions
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Implantation of mixed intracerebral electrodes
5 macro electrodes with micro electrodes are implanted in internal temporal structures (amygdala, anterior and posterior hippocampus, rhinal cortex, posterior para-hippocampal gyrus).
Each electrode has 8 microcontacts, each recording the activity of 0 to 3 neurons (activity of 0 to 120 neurons/patient).
Face detection
Visualization of images of 60 unknown faces and 60 objects that are not faces (object, house, scene, animal, plant, word, letter…). Each image is showed for 500 ms and separated from following image by black screen of 1500 ms. In order to keep patient attention on image, patient will be asked to push a button at color change of fixation cross in the centre of image.
Face individualization
Visualization of images of celebrities (persons known by patient), showed randomly. Each image is showed for 500 ms and separated from following image by black screen of 1500 ms. In order to keep patient attention on image, patient will be asked to push a button at color change of fixation cross in the centre of image.
Several celebrities are showed, with for each the presentation of 60 images different from that celebrity. 1 to 3 celebrities are showed (60 to 180 total images).
Eligibility Criteria
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Inclusion Criteria
* Patient having signed informed consent
* Patient affiliated to social security
* Patient having undergone preliminary medical examination
Exclusion Criteria
* Persons deprived of liberty by juridical or administrative decision
* Patient with severe visual disorders of neurological or ophthalmological origin
* Patients with infection risk according to doctor or surgeon
* Women without effective contraception
* Pregnant or breast-feeding women
18 Years
ALL
No
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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Principal Investigators
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Louis MAILLARD, Pr
Role: PRINCIPAL_INVESTIGATOR
Service de Neurologie CHRU de Nancy - Hôpital Central
Locations
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Service de Neurologie, Hôpital Central, CHRU de Nancy
Nancy, , France
Countries
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Central Contacts
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References
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Le Cam S, Jurczynski P, Jonas J, Koessler L, Colnat-Coulbois S, Ranta R. A Bayesian approach for simultaneous spike/LFP separation and spike sorting. J Neural Eng. 2023 Mar 31;20(2). doi: 10.1088/1741-2552/acc210.
Other Identifiers
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2015-A01951-48
Identifier Type: -
Identifier Source: org_study_id
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