Study of the Neural Basis of Analogical Reasoning

NCT ID: NCT02236832

Last Updated: 2025-09-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

130 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-02-28

Study Completion Date

2021-02-28

Brief Summary

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Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.

Detailed Description

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Conditions

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Frontotemporal Dementia Progressive Supranuclear Palsy Healthy Subjects

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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FTD (frontotemporal dementia) patients

fronto-temporal demential patients

Group Type EXPERIMENTAL

MRI imaging

Intervention Type OTHER

EEG recording

Intervention Type OTHER

Neuropsychological examination

Intervention Type BEHAVIORAL

PSP patients

progressive supra nuclear palsy patients

Group Type EXPERIMENTAL

MRI imaging

Intervention Type OTHER

EEG recording

Intervention Type OTHER

Neuropsychological examination

Intervention Type BEHAVIORAL

healthy controls

healthy control education matched, age matched and sex matched with PSP and FTD patients

Group Type ACTIVE_COMPARATOR

MRI imaging

Intervention Type OTHER

EEG recording

Intervention Type OTHER

Neuropsychological examination

Intervention Type BEHAVIORAL

healthy participants

healthy participants that will participate to the TMS study.

Group Type EXPERIMENTAL

transcranial magnetic stimulation

Intervention Type DEVICE

MRI imaging

Intervention Type OTHER

EEG recording

Intervention Type OTHER

Neuropsychological examination

Intervention Type BEHAVIORAL

healthy young participants

Healthy participants will be included for an EEG study

Group Type EXPERIMENTAL

EEG recording

Intervention Type OTHER

Neuropsychological examination

Intervention Type BEHAVIORAL

Interventions

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transcranial magnetic stimulation

Intervention Type DEVICE

MRI imaging

Intervention Type OTHER

EEG recording

Intervention Type OTHER

Neuropsychological examination

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

Healthy subjects:

* subject affiliated to national health insurance
* informed consent signed
* normal neurological examination
* subject aged at least 20

Patients:

* FTD or PSP diagnostic criteria filled
* patient affiliated to national health insurance
* informed consent signed

Exclusion Criteria

* Severe psychiatric symptomatology and psychotropic drug use
* unability to understand or perform the cognitive tasks.
Minimum Eligible Age

20 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Fondation pour la Recherche Médicale

OTHER

Sponsor Role collaborator

Institut National de la Santé Et de la Recherche Médicale, France

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Richard Levy, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Institut du Cerveau et de la Moelle épinière, Paris

Locations

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ICM (Institut du cerveau et de la Moelle épinière)

Paris, , France

Site Status

Countries

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France

References

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Ovando-Tellez M, Rohaut B, George N, Bieth T, Hugueville L, Ibrahim Y, Courbet O, Naccache L, Levy R, Garcin B, Volle E. Does adding <i>beer</i> to <i>coffee</i> enhance the activation of <i>drinks</i>? An ERP study of semantic category priming. Cogn Neurosci. 2022 Jan-Jun;13(2):61-76. doi: 10.1080/17588928.2021.1940117. Epub 2021 Jul 7.

Reference Type BACKGROUND
PMID: 34232829 (View on PubMed)

Other Identifiers

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140662B-31

Identifier Type: OTHER

Identifier Source: secondary_id

2014-A00649-38

Identifier Type: OTHER

Identifier Source: secondary_id

C14-17'

Identifier Type: -

Identifier Source: org_study_id

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