Investigating the Plasticity of Human Predictive Coding Through Neuromodulation
NCT ID: NCT06374433
Last Updated: 2024-06-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
210 participants
INTERVENTIONAL
2024-06-13
2026-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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Occipital tACS at IAF-2Hz
Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency below the individual alpha frequency (IAF-2 Hz).
Occipital tACS at IAF-2Hz
tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)
Occipital tACS at IAF+2Hz
Transcranial alternating current stimulation (tACS) at occipital sites to modulate the occipital brain areas' activity at a frequency above the individual alpha frequency (IAF+2 Hz).
Occipital tACS at IAF+2Hz
tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)
Frontal tACS at 4-7 Hz
Transcranial alternating current stimulation (tACS) at frontal sites to modulate the frontal brain areas' activity at a frequency within the theta band (4-7 Hz).
Frontal tACS at 4-7 Hz
tACS applied to frontal areas at 4-7 Hz
Sham/placebo tACS
Transcranial alternating current stimulation (tACS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective.
Sham/placebo tACS
tACS is activated only for 30 seconds and then turned off, thus resulting ineffective
Occipital tRNS
Stimulation at occipital sites with transcranial random noise stimulation (tRNS) to modulate occipital brain areas plasticity
Occipital tRNS
tRNS applied to occipital brain regions
Frontal tRNS
Stimulation at frontal sites with transcranial random noise stimulation (tRNS) to modulate frontal brain areas plasticity
Frontal tRNS
tRNS applied to frontal brain regions
Sham/placebo tRNS
Transcranial random noise stimulation (tRNS) is applied only in the first and the last 30 seconds of the experimental procedure, thus resulting ineffective.
Sham/placebo tRNS
tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective
Interventions
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Occipital tACS at IAF-2Hz
tACS applied to occipital areas at 2 Hz below the individual alpha frequency (IAF)
Occipital tACS at IAF+2Hz
tACS applied to occipital areas at 2 Hz above the individual alpha frequency (IAF)
Frontal tACS at 4-7 Hz
tACS applied to frontal areas at 4-7 Hz
Occipital tRNS
tRNS applied to occipital brain regions
Frontal tRNS
tRNS applied to frontal brain regions
Sham/placebo tACS
tACS is activated only for 30 seconds and then turned off, thus resulting ineffective
Sham/placebo tRNS
tRNS is activated only for 30 seconds and then turned off, thus resulting ineffective
Eligibility Criteria
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Inclusion Criteria
* Aged 18-35 years.
* Normal or corrected to normal vision, as per anamnestic investigation.
Exclusion Criteria
* Participants with major neurological disorders (as per anamnestic investigation).
* Participants that are currently under psychopharmacological treatment with tricyclic antidepressants (as per anamnestic investigation).
* Participants with metal implants in the brain, pacemakers, brain stimulators, cochlear implants (as per anamnestic investigation).
18 Years
35 Years
ALL
Yes
Sponsors
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Alessia Santoni
UNKNOWN
Sara Stottmeier
UNKNOWN
Klara Hemmerich
UNKNOWN
Giuseppe Di Dona
UNKNOWN
Luigi Ferini-Strambi
UNKNOWN
Università Vita-Salute San Raffaele
OTHER
Responsible Party
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Luca Ronconi
Professor
Locations
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Università Vita-Salute San Raffaele
Milan, , Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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PREDICOM-01
Identifier Type: -
Identifier Source: org_study_id
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