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" Effect of Affordance of Objects on the Memory: Study in Transcranial Magnetic Stimulation "

NCT ID: NCT02956304

Last Updated: 2017-04-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

30 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-04-03

Study Completion Date

2018-11-30

Brief Summary

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The purpose of this study is determine the involvement of motor system in the memory of manipulable objects. The idea is to stimulate the ventral premotor cortex with transcranial magnetic stimulation to see whether this stimulation will affect memory of manipulable objects.

Detailed Description

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Embodied cognition claims that representations shares processing resources with sensorimotor systems. More specifically, it has been proposed that language comprehension relies on internal simulation of the meaning. For instance, numerous studies have shown that the processing of action-related concepts involve a motor activation similar to when the action is actually performed. However, even if those studies show clearly that action-related concepts involve a motor activation, such activations may be incidental to the activation of their representations, rather than part of it. Another way to show that this motor component takes part in the representation of manipulable objetcs is to investigate whether an impairment of motor system would impair the memory of manipulable object. In this study, investigators will use Transcranial Magnetic Stimulation (TMS) to stimulate ventral premotor cortex (PMv) to see whether this stimulation will affect memory of manipulable objects, but not memory of nonmanipulable objects. For this purpose, three TMS conditions will be assessed: cTBS to inhibit the motor cortex, iTBS to excite the motor cortex, and a SHAM condition as control.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

OTHER

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Group iTBS-cTBS-SHAM

PMv stimulation (iTBS) at session 2, PMv inhibition (cTBS) at session 3, and control (SHAM) at session 4

Group Type OTHER

PMv stimulation (iTBS)

Intervention Type OTHER

PMv stimulation (iTBS)

PMv inhibition (cTBS)

Intervention Type OTHER

PMv inhibition (cTBS)

Control (SHAM)

Intervention Type OTHER

Control (SHAM)

Group iTBS-SHAM-cTBS

PMv stimulation (iTBS) at session 2, control (SHAM) at session 3, and PMv inhibition (cTBS) at session 4

Group Type OTHER

PMv stimulation (iTBS)

Intervention Type OTHER

PMv stimulation (iTBS)

PMv inhibition (cTBS)

Intervention Type OTHER

PMv inhibition (cTBS)

Control (SHAM)

Intervention Type OTHER

Control (SHAM)

Group cTBS-iTBS-SHAM

PMv inhibition (cTBS) at session 2, PMv stimulation (iTBS) at session 3, and control (SHAM) at session 4

Group Type OTHER

PMv stimulation (iTBS)

Intervention Type OTHER

PMv stimulation (iTBS)

PMv inhibition (cTBS)

Intervention Type OTHER

PMv inhibition (cTBS)

Control (SHAM)

Intervention Type OTHER

Control (SHAM)

Group cTBS-SHAM-iTBS

PMv inhibition (cTBS) at session 2, control (SHAM) at session 3, and PMv stimulation (iTBS) at session 4

Group Type OTHER

PMv stimulation (iTBS)

Intervention Type OTHER

PMv stimulation (iTBS)

PMv inhibition (cTBS)

Intervention Type OTHER

PMv inhibition (cTBS)

Control (SHAM)

Intervention Type OTHER

Control (SHAM)

Group SHAM-iTBS-cTBS

control (SHAM) at session 2, PMv stimulation (iTBS) at session 3, and PMv inhibition (cTBS) at session 4

Group Type OTHER

PMv stimulation (iTBS)

Intervention Type OTHER

PMv stimulation (iTBS)

PMv inhibition (cTBS)

Intervention Type OTHER

PMv inhibition (cTBS)

Control (SHAM)

Intervention Type OTHER

Control (SHAM)

Group SHAM-cTBS-iTBS

control (SHAM) at session 2, PMv inhibition (cTBS) at session 3, and PMv stimulation (iTBS) at session 4

Group Type OTHER

PMv stimulation (iTBS)

Intervention Type OTHER

PMv stimulation (iTBS)

PMv inhibition (cTBS)

Intervention Type OTHER

PMv inhibition (cTBS)

Control (SHAM)

Intervention Type OTHER

Control (SHAM)

Interventions

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PMv stimulation (iTBS)

PMv stimulation (iTBS)

Intervention Type OTHER

PMv inhibition (cTBS)

PMv inhibition (cTBS)

Intervention Type OTHER

Control (SHAM)

Control (SHAM)

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 and 35 years
* Right-handers (score between 70 and 100 on the scale of Edinburgh)
* Native language : French
* Not depressed (score lower than 14 in the BDI)
* health insurance
* Consent

Exclusion Criteria

* Psychiatric family history up to the second degree
* Medical treatment, in particular psychotropic being able to affect the memory and the attention
* view or hearing disorders (not compensated)
* neurological histories (epilepsy, alcoholism in particular) or psychiatric or important memory complaints
* Contraindications for the SMT
* contraindications in the MRI
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Paris 5 - Rene Descartes

OTHER

Sponsor Role collaborator

Centre Hospitalier St Anne

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pascale PIOLINO

Role: STUDY_DIRECTOR

University of Paris 5 - Rene Descartes

Benoit CREPON, MD

Role: STUDY_DIRECTOR

CHSA

Locations

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Centre de Recherche Clinique (CRC) - CHSA

Paris, , France

Site Status RECRUITING

Countries

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France

Central Contacts

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Benoit CREPON, MD

Role: CONTACT

Phone: 00 33 1 45 65 87 70

Email: [email protected]

Marie GODARD

Role: CONTACT

Phone: 00 33 1 45 65 77 28

Email: [email protected]

Facility Contacts

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Macarena CUENCA

Role: primary

Cecile Bergot

Role: backup

Other Identifiers

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D15-P13

Identifier Type: -

Identifier Source: org_study_id