Aneuploidy Rates of in Vitro Matured Oocytes

NCT ID: NCT03860064

Last Updated: 2019-11-19

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-03-27

Study Completion Date

2019-09-30

Brief Summary

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In general, nearly 85% of retrieved oocytes are mature and reproductively useful after the retrieval, whereas the remaining percentage are still at metaphase I or germinal vesicle stage (MI: 4% and GV: 11 %, respectively).

The objective of our study is to assess if immature oocytes co-cultured with autologous cumulus cells is a safer strategy than just leaving the oocytes in standard culture.

Detailed Description

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Under controlled ovarian stimulation, patients with normal functional ovarian reserves produce a good number of oocytes at retrieval. However, in addition to quantity, oocyte maturity is an important variable for the success of reproductive technologies. In general, nearly 85% of retrieved oocytes are mature and reproductively useful, whereas the remaining percentage are still at metaphase I or germinal vesicle stage (MI: 4% and GV: 11 %, respectively). Due to the limited expectations held for in vitro maturation in said stimulated cycles, the rescue of immature oocytes is not widely used in current clinical practice and these oocytes are usually discarded due to the possibility of abnormal embryonic development or an increased rate of abortion.

The objective of our study is to assess if immature oocytes co-cultured with autologous cumulus cells is a safer strategy than just leaving the oocytes in standard culture.

Conditions

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Aneuploidy

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Interventions

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Non intervention

Non

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18-35-year-old women
* BMI: \>18 and \< 30 kg/m2
* Normal female karyotype
* Normal uterus and ovaries at transvaginal ultrasound

Exclusion Criteria

* \> 35 years
* PCO syndrome carriers
* Null follicle aspiration
* History of chemotherapy or radiotherapy
Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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IVI Barcelona

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Ivi Barcelona

Barcelona, , Spain

Site Status

Countries

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Spain

Other Identifiers

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1810-BCN-071-ME

Identifier Type: -

Identifier Source: org_study_id

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