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Changes in the Distribution of Mitochondria During Oocyte Maturation

NCT ID: NCT01501292

Last Updated: 2011-12-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-01-31

Study Completion Date

2012-04-30

Brief Summary

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Cytoplasmatic maturation is an important event in the general maturation of of the oocyte. Mitochondria is one of the major organelles involved in the process of cytoplasmatic maturation. The aim of this study is to investigate the presence and distribution of the mitochondria in the cytoplasma of immature oocytes that are retrieved in the routine in-vitro maturation cycle with intracytoplasmatic sperm injection (ICSI). These oocytes will not undergo ICSI because of their immaturity. Usually, they are discarded. In addition to these immature oocytes the investigators shall also investigate the mitochondria in mature oocytes that underwent ICSI but did not become fertilized and are discarded.

Detailed Description

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Conditions

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Infertility

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Immature oocytes (GV, M-I)

Fixation and staining

Intervention Type OTHER

Fixation and staining by MitiTracker Green FM

Observation by laser microscopy

Intervention Type OTHER

Observation with Laser scanning confocal microscopy

Mature oocytes (M-II)

Fixation and staining

Intervention Type OTHER

Fixation and staining by MitiTracker Green FM

Observation by laser microscopy

Intervention Type OTHER

Observation with Laser scanning confocal microscopy

Interventions

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Fixation and staining

Fixation and staining by MitiTracker Green FM

Intervention Type OTHER

Observation by laser microscopy

Observation with Laser scanning confocal microscopy

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Infertile patients needing IVF treatment

Exclusion Criteria

* Patients not requiring the ICSI procedure
Minimum Eligible Age

18 Years

Maximum Eligible Age

44 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hillel Yaffe Medical Center

OTHER_GOV

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hillel Yaffe Medical Center

Hadera, , Israel

Site Status

Countries

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Israel

Central Contacts

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Adrian Ellenbogen, MD

Role: CONTACT

Phone: 972-50-6246722

Email: [email protected]

Other Identifiers

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0095-11-HYMC

Identifier Type: -

Identifier Source: org_study_id