Reproducibility of Dual Beam Doppler Fourier-domain Optical Coherence Tomography in Healthy Subjects
NCT ID: NCT03821467
Last Updated: 2025-05-16
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
20 participants
INTERVENTIONAL
2018-11-19
2025-12-12
Brief Summary
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To enable further development of this technique it is essential to assess short- and long-term reproducibility of DOCT blood flow measurements.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
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Healthy subjects
Dual beam Doppler Fourier-domain OCT (DOCT) Dynamic Vessel Analyzer (DVA) Optical coherence tomography (OCT)
Dual beam Doppler Fourier-domain OCT (DOCT)
Retinal blood flow will be assessed using DOCT.
Dynamic Vessel Analyzer (DVA)
Retinal vessel diameters and oxygen saturation will be measured with the DVA device.
Optical coherence tomography (OCT)
Retinal morphology will be imaged using OCT.
Interventions
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Dual beam Doppler Fourier-domain OCT (DOCT)
Retinal blood flow will be assessed using DOCT.
Dynamic Vessel Analyzer (DVA)
Retinal vessel diameters and oxygen saturation will be measured with the DVA device.
Optical coherence tomography (OCT)
Retinal morphology will be imaged using OCT.
Eligibility Criteria
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Inclusion Criteria
* Non-smokers
* Normal findings in the medical history unless the investigator considers an abnormality to be clinically irrelevant
* Normal ophthalmic findings, ametropy \< 3 Dpt.
Exclusion Criteria
* Treatment in the previous 3 weeks with any drug (except contraceptives)
* Symptoms of a clinically relevant illness in the 3 weeks before the first study day
* Blood donation during the previous 3 weeks
* Pregnancy, planned pregnancy or lactating
* History or family history of epilepsia
18 Years
35 Years
ALL
Yes
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Doreen Schmidl
Associate Professor, MD, PhD
Principal Investigators
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Doreen Schmidl, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Medical University of Vienna, Department of Clinical Pharmacology
Locations
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Medical University of Vienna, Department of Clinical Pharmacology
Vienna, Vienna, Austria
Countries
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Central Contacts
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Facility Contacts
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Doreen Schmidl, MD, PhD
Role: primary
References
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Werkmeister RM, Dragostinoff N, Palkovits S, Told R, Boltz A, Leitgeb RA, Groschl M, Garhofer G, Schmetterer L. Measurement of absolute blood flow velocity and blood flow in the human retina by dual-beam bidirectional Doppler fourier-domain optical coherence tomography. Invest Ophthalmol Vis Sci. 2012 Sep 12;53(10):6062-71. doi: 10.1167/iovs.12-9514.
Doblhoff-Dier V, Schmetterer L, Vilser W, Garhofer G, Groschl M, Leitgeb RA, Werkmeister RM. Measurement of the total retinal blood flow using dual beam Fourier-domain Doppler optical coherence tomography with orthogonal detection planes. Biomed Opt Express. 2014 Jan 28;5(2):630-42. doi: 10.1364/BOE.5.000630. eCollection 2014 Feb 1.
Werkmeister RM, Palkovits S, Told R, Groschl M, Leitgeb RA, Garhofer G, Schmetterer L. Response of retinal blood flow to systemic hyperoxia as measured with dual-beam bidirectional Doppler Fourier-domain optical coherence tomography. PLoS One. 2012;7(9):e45876. doi: 10.1371/journal.pone.0045876. Epub 2012 Sep 18.
Related Links
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Medical University of Vienna, Department of Clinical Pharmacology
Other Identifiers
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OPHT-010418
Identifier Type: -
Identifier Source: org_study_id
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