Dual Wavelength OCT

NCT ID: NCT03843840

Last Updated: 2022-04-12

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2019-02-15
• Study Completion Date: 2020-10-21

Brief Summary

The purpose of this research is the evaluation of a combined coaxial optical coherence tomography (OCT) system to image retina/choroid and to evaluate if post processing of the data can give us insights into property of the tissue imaged.

Detailed Description

Histology studies have shown that many disorders of the retina and choroid such as age-related macular degeneration is associated with a build up abnormal deposits, in the retina or subretinal space. Being able to detect subtle changes in retina and choroidal structure is crucial for better understanding and monitoring of this potentially blinding condition. This study aims to commercially available Spectralis® OCT-system with a central wavelength of 880nm explore the ability of a confocal scanning laser ophthalmoscope (cSLO) for OCT imaging utilising a modified by the addition of a longer wavelength OCT (1075nm , a wavelength deployed on other commercially available OCT scanners). Other commercially available OCT scanners used longer wavelengths to allow deeper penetration and enhanced visualisation of subretinal tissue but less inner retinal detail. Combing both wavelengths could have the advantage of allowing optimum viualisation of inner and subretinal structures. The ability of the systems to acquire repeatable and good quality images of retinal and choroidal structural detail at matching location and compare the results from the two instruments will be evaluated. In addition processing of the images reflectivity with two different wavelength should give us insight into the nature of any abnormal material.

Conditions

AMD; Diabetic Retinopathy; Retinal Degeneration; Retinal Dystrophies

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Diseased Retina

Combined Coaxial Optical Coherence Tomography

Intervention Type: DEVICE

Taking images of the retina with two wavelengths

Interventions

Combined Coaxial Optical Coherence Tomography

Taking images of the retina with two wavelengths

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Age>18
• Ability to consent
• Abnormal reflectivity detected in at least one eye in the retina or choroid on OCT testing undertaken as part of routine
• clinical care

Exclusion Criteria

• Media opacities on conventional OCT testing taken on the day of the study visit, that prevents adequate visualisation of
• the retina and/or choroidal substructures in the opinion of the investigator
• Inability to undertake to undertake two additional OCT scans on each eye in addition to their conventional OCT.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Moorfields Eye Hospital NHS Foundation Trust

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Locations

Moorfields Eye Hospital NHS Foundation Trust, 162 City Road

London, , United Kingdom

Countries

United Kingdom

Other Identifiers

TUFA1040

Identifier Type: -

Identifier Source: org_study_id