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Investigation of Vascular Pat...

Investigation of Vascular Pathology in Eye Diseases Using Using Optical Coherence Tomography Angiography (OCT-A)

NCT ID: NCT02811536

Last Updated: 2022-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

440 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-02-13

Study Completion Date

2022-11-25

Brief Summary

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Comparison of OCTA to conventional imaging modalities for the diagnosis of eye diseases

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Detailed Description

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Optical coherence tomography angiography (OCTA) is a new non-invasive imaging technique that employs motion contrast imaging to high-resolution volumetric blood flow information. OCTA compares the decorrelation signal between sequential OCT b-scans taken at precisely the same cross-section in order to construct a map of blood flow. At present, level 1 evidence of the technology's clinical applications doesn't exist. The investigators plan to compare OCTA as an imaging modality to conventional imaging modalities used in clinical routine.

Conditions

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Retinal Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Diabetic retinopathy

Patients with various degrees of diabetic retinopathy

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Retinal detachment

Patients with a history of retinal detachment

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Retinal vein occlusion

Patients with a history of retinal vein occlusion

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Arterial hypertension

Patients with a history of arterial hypertension

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Carotid artery occlusion

Patients with a history of carotid artery occlusion

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Age related macular degeneration

Patients with a history of Age related macular degeneration

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Macroaneurysms

Patients with a history of retinal macroaneurysms

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Central serous chorioretinopathy

Patients with a history of central serous chorioretinopathy

optical coherence tomography angiography

Intervention Type DEVICE

Imaging with optical coherence tomography angiography

Interventions

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optical coherence tomography angiography

Imaging with optical coherence tomography angiography

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

Patients from the Department of Ophthalmology, University Hospital Bern requiring conventional imaging for eye disease and willing to sign informed consent Patients of 18 years or older

Exclusion Criteria

Patients not willing or able to sign informed consent Patients younger than 18 years Patients with epilepsy Patients having had photodynamic therapy within the last 48 hours prior to imaging with OCTA

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Insel Gruppe AG, University Hospital Bern

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Martin Zinkernagel, Prof.MD PhD

Role: STUDY_CHAIR

Inselspital, University Clinic for Ophthalmology

Locations

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Inselspital Bern, Department of Ophthalmology

Bern, , Switzerland

Site Status

Countries

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Switzerland

References

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Tian M, Zeng G, Zinkernagel M, Tappeiner C, Wolf S, Munk MR. Assessment of choriocapillaris and choroidal vascular changes in posterior uveitis using swept-source wide-field optical coherence tomography angiography. Br J Ophthalmol. 2024 Feb 21;108(3):386-390. doi: 10.1136/bjo-2022-322209.

Reference Type DERIVED

PMID: 36627172 (View on PubMed)

Tian M, Tappeiner C, Zinkernagel MS, Huf W, Wolf S, Munk MR. Evaluation of vascular changes in intermediate uveitis and retinal vasculitis using swept-source wide-field optical coherence tomography angiography. Br J Ophthalmol. 2019 Sep;103(9):1289-1295. doi: 10.1136/bjophthalmol-2018-313078. Epub 2018 Dec 11.

Reference Type DERIVED

PMID: 30538102 (View on PubMed)

Other Identifiers

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OCTA Bern

Identifier Type: -

Identifier Source: org_study_id

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