High-resolution Imaging of Corneal Lesions With Optical Coherence Tomography (OCT) - A Pilot Study

NCT ID: NCT01753583

Last Updated: 2020-02-20

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-07-23

Study Completion Date

2016-03-01

Brief Summary

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Corneal lesions such as corneal abrasions and corneal infiltrates are common in clinical practice. The current study seeks to investigate whether high-resolution OCT is suitable for imaging of these corneal lesions. The present study has the character of a pilot study and the results are intended to be used to develop a standardized protocol for imaging and analysis of these corneal lesions. Based on this protocol, further studies investigating the pathophysiology of corneal lesions or evaluating therapeutic success can be planned.

Detailed Description

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Conditions

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Corneal Abrasions Corneal Infiltrates

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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10 patients with corneal abrasions

Group Type EXPERIMENTAL

Optical Coherence Tomography (OCT)

Intervention Type DEVICE

High-resolution OCT imaging of the cornea

Slit lamp biomicroscopy

Intervention Type OTHER

Slit lamp biomicroscopy with fluorescein staining and slit lamp photograph

10 patients with corneal infiltrates

Group Type EXPERIMENTAL

Optical Coherence Tomography (OCT)

Intervention Type DEVICE

High-resolution OCT imaging of the cornea

Slit lamp biomicroscopy

Intervention Type OTHER

Slit lamp biomicroscopy with fluorescein staining and slit lamp photograph

Interventions

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Optical Coherence Tomography (OCT)

High-resolution OCT imaging of the cornea

Intervention Type DEVICE

Slit lamp biomicroscopy

Slit lamp biomicroscopy with fluorescein staining and slit lamp photograph

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Men and women aged over 18 years
* Newly diagnosed corneal abrasion or corneal infiltrate

Exclusion Criteria

* Recurrent corneal erosion
* Participation in a clinical trial in the previous 3 weeks
* Presence of any abnormalities preventing reliable measurements as judged by the investigator
* Any contraindication for topical application of Novain 0.4% eye drops for topical anesthesia or of Minims-Fluorescein Sodium eye drops for fluorescein staining
* Pregnancy, planned pregnancy or lactating
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medical University of Vienna

OTHER

Sponsor Role lead

Responsible Party

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Gerhard Garhofer

Assoc. Prof. PD Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Clinical Pharmacology, Medical University of Vienna

Vienna, , Austria

Site Status

Countries

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Austria

Other Identifiers

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OPHT-041112

Identifier Type: -

Identifier Source: org_study_id

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