Spectral-domain Optical Coherence Tomography Findings in Retinal Vessel Occlusion

NCT ID: NCT03061526

Last Updated: 2023-03-02

Basic Information

• Recruitment Status: UNKNOWN
• Total Enrollment: 100 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-05-01
• Study Completion Date: 2023-12-31

Brief Summary

Retinal vessel occlusions might lead to ischemia of the inner retina, more severe so in artery occlusions. Intracellular edema may develop and decrease transparency of those layers, showing retinal edema. In spectral domain optical coherence tomography (SD-OCT) retinal reflectivity changes as a result of retinal edema. The investigators examine the reflectivity changes of different retinal layers between healthy eyes and eyes with retinal artery occlusion and ischemic or non-ischemic vein occlusions. Aim of the study is to evaluate whether those changes can be used to measure the level of ischemia in the inner retina.

Detailed Description

Several studies tried to classify retinal ischemia due to retinal artery or vein occlusion into different grades. In some cases prognosis is dependent on grade of severity, especially in cases of retinal vein occlusion. State of the art to Diagnose the severity of retinal ischemia is lfuorescein angiography. However, this technique is invasive and might cause Problems like anaphylactic shock. Optical coherence tomography is a non-invasive technique, but up to now there is no standardized method to quantify the grade of severity of retinal ischemia in such conditions like retinal vessel occlusion. The study hope to find criteria by which such a classification can be constructed.

Conditions

Retinal Ischemia

Study Design

• Observational Model Type: COHORT
• Study Time Perspective: RETROSPECTIVE

Interventions

optical coherence tomography

measurement of reflectivity in different retinal layers based on optical coherence tomography findings

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• acute Retinal vessel occlusion on one eye
• healthy contralateral eye
• examined with spectral Domain optical coherence tomography

Exclusion Criteria

• retinal occlusion older than 1 week
• OCT Image not obtainable/missing

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Technische Universität Dresden

OTHER

Sponsor Role: lead

Responsible Party

Dr.med. Egbert Matthé

Principal Investigator

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Egbert Matthé, MD

Role: PRINCIPAL_INVESTIGATOR

Technical University Dresden

Locations

University Eye Hospital

Dresden, , Germany

Site Status: RECRUITING

Countries

Germany

Central Contacts

Egbert Matthé, MD

Role: CONTACT

egbert.matthe@uniklinikum-dresden.de

+493514583381

Olga Furashova

Role: CONTACT

Facility Contacts

Egbert Matthé, MD

Role: primary

egbert.matthe@uniklinikum-dresden.de

+493514583381

References

Matthe E, Wittig D, Kuhn M, Eulitz P, Schoen K, Sandner D, Furashova O. Manual measurement of SD-OCT images of hyperreflective retinal layers in acute retinal vessel occlusion is reliable, repeatable and reproducible. Sci Rep. 2025 Oct 3;15(1):34471. doi: 10.1038/s41598-025-20086-7.

Reference Type: DERIVED

PMID: 41044164 (View on PubMed)

Other Identifiers

EK 417102016

Identifier Type: -

Identifier Source: org_study_id