Insights From the Retina on Cerebral Microvascular Dysfunction in Haemorrhagic Stroke
NCT ID: NCT04363619
Last Updated: 2022-08-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
14 participants
INTERVENTIONAL
2021-02-23
2022-07-28
Brief Summary
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Detailed Description
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* To evaluate the feasibility of fundoscopy, OCT and OCTA imaging in the environment of a Neurocritical Care Unit (NCCU)
* To detect, quantify and associate microvascular changes in the retina with signs of micro-vessel disease in ICH and DCI in aSAH
Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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Controls
OCT and OCTA
Fundoscopy, OCT and OCTA will be performed 4 times in patients
ICH
OCT and OCTA
Fundoscopy, OCT and OCTA will be performed 4 times in patients
aSAH
OCT and OCTA
Fundoscopy, OCT and OCTA will be performed 4 times in patients
Interventions
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OCT and OCTA
Fundoscopy, OCT and OCTA will be performed 4 times in patients
Eligibility Criteria
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Inclusion Criteria
* Primary ICH or aSAH with symptoms onset \< 3 days
* 18 to unlimited years of age
* Signed informed consent obtained from legal representative or patient ICH group
* Primary ICH localized either in basal ganglia, thalamus, pons or cerebellum aSAH group
* Ruptured aneurysm visualized in contrast-enhanced computed tomography (angio-CT), MRI or cerebral angiography Control group
* Stroke due to perimesencepahlic subarachnoid hemorrhage, arteriovenous malformation or isolated traumatic brain injury
Exclusion Criteria
* Cerebral amyloid angiopathy or other neurodegenerative disease
* History of migraine with aura or ischemic stroke
* Contraindication for pupil dilation (intracranial hypertension, allergy against mydriatics, angle closure glaucoma)
* Any pre-existing or manifest ocular condition affecting either the integrity of retinal vessels, transparency of optical media or the risk of acute angle closure glaucoma
* Concomitant instable critical illness (e.g. sepsis, multi-organ failure)
* Intracranial pressure \> 20mmHg and refractory to cerebrospinal fluid drainage
* Pregnancy
18 Years
ALL
No
Sponsors
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University of Zurich
OTHER
Responsible Party
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Emanuela Keller
Prof. Dr.
Locations
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University Hospital Zurich
Zurich, , Switzerland
Countries
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Other Identifiers
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2020-01524
Identifier Type: -
Identifier Source: org_study_id
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