The Effects of Different General Anesthetics on Serum Folic Acid and Homocysteine Concentrations in Children
NCT ID: NCT03746340
Last Updated: 2018-11-19
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
40 participants
OBSERVATIONAL
2018-11-07
2019-03-31
Brief Summary
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Detailed Description
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Prospective study：Ten infants and young children (less than 3 years old) who underwent general anesthesia from November 7, 2018 to December 31, 2018 in Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. Inhalation of 1-8% concentration of sevoflurane for general anesthesia induced intubation, followed by sevoflurane 2.0 \~ 2.5 Vol% inhalation maintenance, according to the intraoperative situation to add opioids. Patients maintained a bispectral index (BIS) monitoring between 50 and 60. After induction of general anesthesia in all patients, Serum folate levels were measured before the start of surgery, every 1 hour during surgery, and at the end of surgery.
Conditions
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Study Design
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OTHER
OTHER
Study Groups
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Anesthetic
Sevoflurane Group Propofol Group
Propofol
Propofol group: intravenous Propofol (2.0mg / kg) for general anesthesia induction, maintained for 30\~60s. Continuous intravenous infusion of Propofol (7\~8 mg·kg-1·h-1) with a syringe pump maintains a smooth general anesthetic sedative effect.
Sevoflurane
Sevoflurane group: Inhalation of 1-8% sevoflurane for induction.Then Inhalation of sevoflurane (2.0\~2.5Vol%) was maintained
Interventions
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Propofol
Propofol group: intravenous Propofol (2.0mg / kg) for general anesthesia induction, maintained for 30\~60s. Continuous intravenous infusion of Propofol (7\~8 mg·kg-1·h-1) with a syringe pump maintains a smooth general anesthetic sedative effect.
Sevoflurane
Sevoflurane group: Inhalation of 1-8% sevoflurane for induction.Then Inhalation of sevoflurane (2.0\~2.5Vol%) was maintained
Eligibility Criteria
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Inclusion Criteria
2. Those who did not participate in other clinical trials within 3 months
3. No acute infectious diseases, systemic diseases
4. The family member of the child agrees to the test and signs the informed consent form.
Exclusion Criteria
2. severe liver and kidney damage
3. Hemodynamic instability (shock, blood pressure drop \> 30% of basal blood pressure)
4. Children with egg and milk allergy
5. Children with a family history of malignant hyperthermia
1 Year
3 Years
ALL
No
Sponsors
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Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
OTHER
Responsible Party
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Principal Investigators
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Hong Jiang, MD,PhD
Role: PRINCIPAL_INVESTIGATOR
Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
Locations
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Shanghai Ninth People's Hospital , Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China
Countries
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Other Identifiers
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SH9H-2018-T53-2
Identifier Type: -
Identifier Source: org_study_id
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