The Effect of Anesthetics on Oxidative Stress and Apoptosis Status in Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

47 participants

Study Classification

INTERVENTIONAL

Study Start Date

2015-09-30

Study Completion Date

2016-06-30

Brief Summary

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The purpose of this study is to determine whether Propofol and Sevoflurane affect the oxidative stress and apoptosis status in children undergoing hypospadias repair surgery.

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Detailed Description

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Conditions

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Anesthesia, General

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

SINGLE

Participants

Study Groups

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Sevoflurane General anesthesia

Anesthesia was induced with 8% sevoflurane with 8L/min oxygen. Anesthesia was maintained with 1-3% sevoflurane in oxygen/air mixture.

Group Type EXPERIMENTAL

Sevoflurane

Intervention Type DRUG

Propofol General anesthesia

Anesthesia was induced with propofol 4mg/kg. Anesthesia was maintained with propofol 7-12mg/kg/h.

Group Type EXPERIMENTAL

Propofol

Intervention Type DRUG

Interventions

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Sevoflurane

Intervention Type DRUG

Propofol

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* American Society of Anesthesiology (ASA) I-II, undergoing selective surgery for hypospadias repair.

Exclusion Criteria

* a history of developmental delay or mental retardation, which could make observational pain intensity assessment outside the norm;
* a history of central nervous system diseases;
* a known or suspected coagulopathy;
* a known allergy to any of the study drugs;
* abnormalities of the sacrum and any signs of infection at the site of the proposed caudal block.

Minimum Eligible Age

1 Year

Maximum Eligible Age

3 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

No