The Difference in Cerebral Oxygenation Between Propofol and Sevoflurane

NCT ID: NCT01757561

Last Updated: 2015-09-18

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

144 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-12-31

Study Completion Date

2014-03-31

Brief Summary

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the purpose of this study is to investigate whether propofol and sevoflurane have difference effect on cerebral oxygenation .

Detailed Description

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the purpose of this study:(1) to investigate the incidence of preoperative cerebral oxygenation abnormity (SjvO2 \<55%) and its relationship with intraoperative cerebral desaturation and POCD. (2) To investigate the change of intraoperative cerebral oxygen supply and demand balance and the incidence of cerebral desaturation in patients with abnormal preoperative cerebral oxygenation during sevoflurane anesthesia. (3)To investigate the incidence of early POCD in patients with abnormal preoperative cerebral oxygenation during sevoflurane and propofol anesthesia.

Conditions

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Cerebral Hypoxia Postoperative Cognitive Dysfunction

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Propofol-Abnormal

patients with preoperative SjvO2\<55%,using the TIVA technology with propofol,

propofol

Intervention Type PROCEDURE

use total intravenous anesthesia with propofol

Propofol-Normal

patients with preoperative SjvO2≥55%,using the TIVA technology with propofol,

propofol

Intervention Type PROCEDURE

use total intravenous anesthesia with propofol

Sevoflurane-Abnormal

patients with preoperative SjvO2\<55%,using the VIMA technology with sevoflurane,

sevoflurane

Intervention Type PROCEDURE

use inhalation anesthesia with sevoflurane

Sevoflurane-Normal

patients with preoperative SjvO2≥55%,using the VIMA technology with sevoflurane,

sevoflurane

Intervention Type PROCEDURE

use inhalation anesthesia with sevoflurane

Interventions

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propofol

use total intravenous anesthesia with propofol

Intervention Type PROCEDURE

sevoflurane

use inhalation anesthesia with sevoflurane

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* scheduled to take major surgery under general anesthesia over 18 years old classified as ASA class three or less

Exclusion Criteria

* have a diagnosis of cerebrovascular disorder
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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First Affiliated Hospital, Sun Yat-Sen University

OTHER

Sponsor Role lead

Responsible Party

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Jun-ying Guo

Attending physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Guo J Ying, Master

Role: STUDY_CHAIR

the First Affiliated Hospital of SunYetSen University

Locations

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the First Affiliated Hospital of Sun YetSen University

Guangzhou, Guangdong, China

Site Status

Countries

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China

Other Identifiers

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伦审[2012]324号

Identifier Type: -

Identifier Source: org_study_id

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