Anaesthetic and Pediatric Living Related Liver Transplantation

NCT ID: NCT03024840

Last Updated: 2017-01-19

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2016-12-31
• Study Completion Date: 2017-12-31

Brief Summary

To study the effect of different anaesthetic methods on pediatric neurocognitive development and cerebral injury during pediatric living related liver transplantation .

Detailed Description

Since the 1960 s, with the successful development of liver transplantation, it has become an important method for the treatment of patients with end-stage liver disease.Biliary atresia1 is the most frequent causes of pediatric end-stage liver disease,.The morbidity of congenital biliary atresia is 1/8000-18, 0002 ,which influence the patients' overall growth and development situation. The rising of living donor liver transplantation has provide children with the chance of a timely treatment since the 1980 s, It is no doubt that pediatric liver transplantation is facing with many complications, including the most importance of neurocognitive development .Now the researches of neurological complications is less .According to statistics, the incidence of neurological complications after pediatric liver transplantation was 8% - 46% . So it is necessary to research the neurological complications and brain protection strategy .Previous studies have studied that some anaesthetic have uncertain affect on the development of children.

Conditions

Liver Transplantation; Children

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

sevoflurane

Sevoflurane is inhalated with 1%-2% after anesthesia induction until end of the surgery.

Group Type: EXPERIMENTAL

Sevoflurane

Intervention Type: DRUG

Sevoflurane: 1%\~2%

propofol

Propofol is injected with 9-15 mg/kg/h after anesthesia induction until end of the surgery.

Group Type: EXPERIMENTAL

Propofol

Intervention Type: DRUG

Propofol: 9-15 mg/kg/h

Interventions

Sevoflurane

Sevoflurane: 1%\~2%

Intervention Type: DRUG

Propofol

Propofol: 9-15 mg/kg/h

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Children with end-stage liver disease Children with biliary atresia

Exclusion Criteria

• pre-existing cerebral disease second liver transplantation

• Minimum Eligible Age: 4 Months
• Maximum Eligible Age: 12 Months
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Tianjin First Central Hospital

OTHER

Sponsor Role: lead

Responsible Party

Wenli Yu

Wenli Yu,PhD ,Department of Anesthesiology,Tianjin First Center Hospital

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

No.24 Fukang Road,Nankai District

Tianjin, Tianjin Municipality, China

Countries

China

Other Identifiers

2016N0039KY

Identifier Type: -

Identifier Source: org_study_id