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The Effect of Chronic Anemia on Safety Period of Tracheal Intubation in Gynecology Patients

NCT ID: NCT01968525

Last Updated: 2013-10-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

45 participants

Study Classification

INTERVENTIONAL

Study Start Date

2013-04-30

Study Completion Date

2013-09-30

Brief Summary

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1. Every individual receiving a general anesthetic is at potential risk for developing a ''cannot intubate-cannot ventilate'' situation following anesthetic induction.
2. Building up of oxygen reserves assumes great significance as this provides a longer duration of non-hypoxic apnea should one be faced with an unanticipated difficult airway.
3. The main physiological functions of red blood cell hemoglobin are to deliver oxygen to the peripheral tissues.
4. During anemia, a reduction in blood oxygen content occurs as a result of reduced Hb while arterial oxygenation and oxyhemoglobin saturation remain high.
5. Previous studies about the duration of non-hypoxic apnoea focus on methods to improve the safety period of tracheal intubation.
6. To our knowledge, there is no literature about the duration of non-hypoxic apnoea of anemia patients.
7. The aim of this study was to assess the effect of chronic anemia on the duration of non-hypoxic apnoea during induction of anaesthesia.

Detailed Description

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After breathing for 3 minutes, anesthesia induction was conducted. The endotracheal tube position was confirmed after anesthesia induction. Patients were left apneic with the endotracheal tube open to room air. The non-hypoxic apneic period was recorded as the time (in seconds) taken for the drop in pulse saturation to 90% or an apneic period of 10 min elapsed, whichever was earlier.

Conditions

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Chronic Anemia

Keywords

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anemia non-hypoxic apnoea tracheal intubation anesthesia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

HEALTH_SERVICES_RESEARCH

Blinding Strategy

NONE

Study Groups

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Group A

the hemoglobin is \>12g/L in patients from group A.

Group Type EXPERIMENTAL

pre-oxygen

Intervention Type BIOLOGICAL

3 min of preoxygenation before anesthesia induction.

Group B

Hb 9-12g/L

Group Type EXPERIMENTAL

pre-oxygen

Intervention Type BIOLOGICAL

3 min of preoxygenation before anesthesia induction.

Group C

Hb\<9g/L

Group Type EXPERIMENTAL

pre-oxygen

Intervention Type BIOLOGICAL

3 min of preoxygenation before anesthesia induction.

Interventions

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pre-oxygen

3 min of preoxygenation before anesthesia induction.

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

1. patients scheduled to undergo general anesthesia
2. American Society of Anesthesiologists Performance Status 1-2
3. adults

Exclusion Criteria

1. Individuals with significant cardiorespiratory or cerebrovascular disease,
2. difficult intubation
3. history of epilepsy
4. body mass index \>25 kg/m2,
5. and those who had smoking history in past 6 months
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Fudan University

OTHER

Sponsor Role lead

Responsible Party

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Geng guiqi

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Guiqi Geng, PhD

Role: STUDY_DIRECTOR

Department of anesthesiology, obstetrics and genecology hospital, FuDan university

Locations

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Fudan university

Shanghai, Shanghai Municipality, China

Site Status

Countries

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China

Other Identifiers

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199987

Identifier Type: -

Identifier Source: org_study_id