Effect of Location of Tetanic Stimuli on Photoplethysmogram Under General Anesthesia

NCT ID: NCT05899686

Last Updated: 2024-05-16

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-01-27

Study Completion Date

2016-05-12

Brief Summary

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The effect of the location of tetanic stimulus on photoplethysmography signals will be studied in patients under general anesthesia.

Detailed Description

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A 5 second 100 Hz 70 mA tetanic stimulus will be applied to three different locations (Ulnar nerve, Facial nerve, Posterior Tibial nerve) in a random order in patients who are under general anesthesia. Tetanic stimuli are used routinely during general anesthesia to assess effectiveness of neuromuscular blockade. These tetanic stimuli are noxious stimuli that elicit a stress response which can be quantified using photoplethysmography. This study investigates if the magnitude of the tetanus induced stress response is dependent on the location of the tetanic stimulus as measured by photoplethysmography.

Conditions

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Stress Reaction

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Each participant will receive three tetanic stimuli. They are applied to the same three anatomical locations in each subject, but the order at which they are delivered to these locations will be random.
Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Tetanic Stimulus

all participants receive the same intervention, which is three tetanic stimuli applied to three different anatomical locations. The three anatomical locations are identical in all subjects.

Group Type EXPERIMENTAL

Tetanic Stimulus

Intervention Type DEVICE

5 second 100 Hz 70 mA tetanic stimulus will be applied to three different anatomical locations in each subject.

Interventions

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Tetanic Stimulus

5 second 100 Hz 70 mA tetanic stimulus will be applied to three different anatomical locations in each subject.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Surgical patients
* Undergoing general anesthesia
* Able to consent in english
* 18 years of age or older

Exclusion Criteria

* Under 18 years of age
* unable to consent in english
* receiving regional anesthesia
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of California, San Francisco

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pekka Talke, MD

Role: PRINCIPAL_INVESTIGATOR

University of California, San Francisco

Locations

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University of California San Francisco

San Francisco, California, United States

Site Status

Countries

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United States

Other Identifiers

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PT1502

Identifier Type: -

Identifier Source: org_study_id

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