Neurotoxicity of Anesthesia in Middle Aged Patients

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

600 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-03-01

Study Completion Date

2022-09-01

Brief Summary

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for the last 20 years, the increasing reports from non-human studies have raised suspicion that general anesthetics may cause neurotoxic changes in the developing brain that lead to adverse neurodevelopmental outcomes later in life.there are several case reports of reversible smell and taste dysfunction following exposure to general anesthesia suggesting a possible relationship between anesthetic agents and olfactory dysfunction.

this study is to assess the possible neurotoxicity of sevoflurane,isoflurane,and propofol based anesthesia guided by olfactory changes

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Detailed Description

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the primary inhibitory neurotransmitter GABA is found in neuronal synapses involving olfactory bulb. So, the involvement of common GABA pathway implies a possible interaction of general anesthetics with olfactory function.

olfactory identification is an associative memory which is found to be facilitated by action of melatonin. involvement of GABA receptor in the transfer of light information from suprachiasmatic nuclei to pineal gland suggests possible interaction of melatonin and anesthetic agents.

the aim of the study is to evaluate the possible neurotoxicity of sevoflurane,isoflurane,and propofol based anesthesia guided by olfactory changes

Conditions

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Anesthesia; Adverse Effect

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

various anesthetic agents used in both general and regional anesthesia

Intervention Type DRUG

Other Intervention Names

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Sevoflurane Isoflurane Propofol infusion

Eligibility Criteria

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Inclusion Criteria

* patients aged 18-50 years
* both sex
* American society of Anesthesiologists' physical status I and II
* elective surgery of duration 90-120 minutes

Exclusion Criteria

* patients's refusal
* recent airway infection
* allergic rhinitis
* nasal polyps
* history of alcoholism
* smoking
* pregnancy
* menstruating female
* mental retardation
* psychiatric illness
* neurosurgical or oto-rhino-laryngeal surgery
* history of olfactory deficits or cognitive impairment
* CNS disease e.g. epilepsy
* history of first degree relative with alzheimer's disease,dementia, or cognitive dysfunction
* those who are unable to answer the tests themselves

Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No