Study Results
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Basic Information
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RECRUITING
200 participants
OBSERVATIONAL
2018-04-05
2030-09-30
Brief Summary
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Detailed Description
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Nevertheless, in some patients, non-invasive evaluation does not give formal answer. In these subjects, it is then necessary to carry out a second step, consisting of an invasive exploration by implantation of intracerebral electrodes during a Stereoelectroencephalography (SEEG).
Due to its temporal and spatial resolution, the SEEG allows, besides the precise determination of the EZ, to carry out a functional mapping of the cortical regions likely to be included in cortectomy. Conventionally, this mapping is carried out on the basis of the cortical electrical stimulations applied to the implanted electrodes. If this approach is very robust for exploring primary functions such as motor skills or language, it cannot be used to evaluate more complex cognitive tasks such as face recognition or attention. Essential cognitive tasks on a daily basis.
This has led to the development in recent years, in Grenoble, of a complementary approach to cerebral stimulation: Dynamic Spectral Imaging (ISD). Numerous experimental paradigms have demonstrated that the realization of a cognitive task associates with the generation within the cortical regions involved in its treatment of a particular cortical activity. This activity is characterized by oscillations of the cortical rhythm in high frequencies (\> 40 Hz), called gamma activities. The ISD thus consists in mapping this gamma activity during various cognitive tasks, thus making it possible to study more widely the complexity of the cognitive functions.
MAPCOG\_SEEG aims to collect the cerebral recording of the patients who have performed this cognitive exploration to be able to in fine propose an Atlas of human cognition which takes advantage of the very rich information in terms of spatial and temporal resolution of the SEEG. Furthermore, it will exactly allow more to understand the impact of the epilepsy and the surgery of the epilepsy on the cognition.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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SEEG Group
Group with SEEG analysis (Pre-surgical SEEG assessment)
SEEG Group
Visual and quantitative SEEG signal analysis. As available, collection of behavioral and neuropsychological postsurgical data
Interventions
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SEEG Group
Visual and quantitative SEEG signal analysis. As available, collection of behavioral and neuropsychological postsurgical data
Eligibility Criteria
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Inclusion Criteria
* Justified SEEG exploration in the context of presurgical assessment of epilepsy
* Written non-opposition to study participation
* Intellectual capacities compatible with the compliance in the cognitive tasks
Exclusion Criteria
* Impossibility of collecting information on exposure (recent arrival in France, foreign language, etc.)
* Pregnant women (Contraindication to SEEG exploration)
18 Years
65 Years
ALL
No
Sponsors
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University Hospital, Grenoble
OTHER
Responsible Party
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Principal Investigators
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Philippe Kahane, MD/PhD
Role: PRINCIPAL_INVESTIGATOR
University Hospital, Grenoble
Marcela Perrone-Bertolotti, PhD
Role: STUDY_CHAIR
Centre National de la Recherche Scientifique, France
Locations
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University Hospital, Grenoble
Grenoble, , France
CHRU Nancy
Nancy, , France
Hôpital Ste Anne
Paris, , France
CHU Rennes
Rennes, , France
Countries
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Central Contacts
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Facility Contacts
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References
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Lachaux JP, Axmacher N, Mormann F, Halgren E, Crone NE. High-frequency neural activity and human cognition: past, present and possible future of intracranial EEG research. Prog Neurobiol. 2012 Sep;98(3):279-301. doi: 10.1016/j.pneurobio.2012.06.008. Epub 2012 Jun 26.
Baciu M, Perrone-Bertolotti M. What do patients with epilepsy tell us about language dynamics? A review of fMRI studies. Rev Neurosci. 2015;26(3):323-41. doi: 10.1515/revneuro-2014-0074.
Combrisson E, Perrone-Bertolotti M, Soto JL, Alamian G, Kahane P, Lachaux JP, Guillot A, Jerbi K. From intentions to actions: Neural oscillations encode motor processes through phase, amplitude and phase-amplitude coupling. Neuroimage. 2017 Feb 15;147:473-487. doi: 10.1016/j.neuroimage.2016.11.042. Epub 2016 Nov 30.
Ossandon T, Vidal JR, Ciumas C, Jerbi K, Hamame CM, Dalal SS, Bertrand O, Minotti L, Kahane P, Lachaux JP. Efficient "pop-out" visual search elicits sustained broadband gamma activity in the dorsal attention network. J Neurosci. 2012 Mar 7;32(10):3414-21. doi: 10.1523/JNEUROSCI.6048-11.2012.
Perrone-Bertolotti M, Vidal JR, de Palma L, Hamame CM, Ossandon T, Kahane P, Minotti L, Bertrand O, Lachaux JP. Turning visual shapes into sounds: early stages of reading acquisition revealed in the ventral occipitotemporal cortex. Neuroimage. 2014 Apr 15;90:298-307. doi: 10.1016/j.neuroimage.2013.12.027. Epub 2013 Dec 24.
Perrone-Bertolotti M, Kujala J, Vidal JR, Hamame CM, Ossandon T, Bertrand O, Minotti L, Kahane P, Jerbi K, Lachaux JP. How silent is silent reading? Intracerebral evidence for top-down activation of temporal voice areas during reading. J Neurosci. 2012 Dec 5;32(49):17554-62. doi: 10.1523/JNEUROSCI.2982-12.2012.
Other Identifiers
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2017-A03248-45
Identifier Type: OTHER
Identifier Source: secondary_id
38RC17.357
Identifier Type: -
Identifier Source: org_study_id
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