The Effects of Unfiltered (Turkish) Coffee Consumption on Cardiovascular Risk Parameters

NCT ID: NCT03495336

Last Updated: 2018-04-12

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 28 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2017-03-22
• Study Completion Date: 2017-10-22

Brief Summary

Purpose/Objective: The aim of this study is to investigate the impact of boiled unfiltered (Turkish) coffee consumption on the plasma cardiovascular risk parameters of healthy subjects. The study also explores whether two unfiltered boiled (Turkish) coffee beverages that differ in content due to different roasting degrees will differentially affect cardiovascular biomarkers.

Methods: In this crossover intervention study, healthy, nonsmoking, habitual Turkish coffee drinkers (n=28) were randomized to consume at least 3 cups of Light (LR) or Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks. Subsequent to each coffee abstinence period, both groups received the alternative intervention. After the first WO and the coffee intervention periods, anthropometric measures, blood pressure, heart rate and 13 biochemical parameters were collected and dietary records were completed.

Detailed Description

Background: Considerable controversy exists regarding the link between coffee consumption and cardiovascular disease (CVD) risk. It has been shown that different coffee preparation and brewing methods influence the concentration of compounds present in the final coffee brew. Unlike coffee traditionally consumed in the western world, Turkish coffee is not drip filtered, but rather its method of preparation involves slowly boiling water that is mixed with thinly ground coffee beans. This style of preparation results in a greater amount of biologically active components (caffeine and diterpenes) remaining in the liquid. In addition to preparation styles, roasting process greatly affects the chemical composition of the coffee. Coffee types differing in content of major constituents differ with regard to cardiovascular health effects.

Purpose/Objective: The aim of this study is to investigate the impact of boiled unfiltered (Turkish) coffee consumption on the plasma cardiovascular risk parameters of healthy subjects. The study also explores whether two unfiltered boiled (Turkish) coffee beverages that differ in content due to different roasting degrees will differentially affect cardiovascular biomarkers.

Methods: In this crossover intervention study, healthy, nonsmoking, habitual Turkish coffee drinkers (n=28) were randomized to consume at least 3 cups of Light (LR) or Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks. Subsequent to each coffee abstinence period, both groups received the alternative intervention. After the first WO and the coffee intervention periods, anthropometric measures, blood pressure, heart rate and 13 biochemical parameters were collected and dietary records were completed.

Conditions

Cardiovascular Diseases

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Washout period

Coffee abstention phase for 2 weeks.

Group Type: EXPERIMENTAL

coffee abstention phase

Intervention Type: OTHER

no coffee consumption for 2 weeks

Light roast coffee (LR)

Participants will follow LR Coffee consumption procedure and consume at least 3 cups of Light (LR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks.

Group Type: EXPERIMENTAL

LR Coffee consumption

Intervention Type: OTHER

for 4 weeks participants consumed only LR Turkish coffee

Second washout period

coffee abstention phase for 2 weeks

Group Type: EXPERIMENTAL

coffee abstention phase

Intervention Type: OTHER

no coffee consumption for 2 weeks

Dark roast coffee (DR)

Participants will follow DR Coffee consumption procedure and consume at least 3 cups of Dark (DR) roast Turkish coffee brews per day for 4 weeks after a washout period (WO) of 2 weeks.

Group Type: EXPERIMENTAL

DR Coffee consumption

Intervention Type: OTHER

for 4 weeks participants consumed only DR Turkish coffee

Interventions

coffee abstention phase

no coffee consumption for 2 weeks

Intervention Type: OTHER

LR Coffee consumption

for 4 weeks participants consumed only LR Turkish coffee

Intervention Type: OTHER

DR Coffee consumption

for 4 weeks participants consumed only DR Turkish coffee

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Regular Turkish coffee consumer ≥ 1 cups/day
• Body mass index (BMI) 18.5-24.9 kg/m2 )
• Non-smoker or former smoker (more than a year)
• Willingness to abstain from coffee drinking
• Willingness to consume ≥ 3 cups/day of Turkish coffee

Exclusion Criteria

• Acute or chronic diseases
• Severe illness with in-patient treatment during last 3 months
• Use of regular medication or any supplements
• Weight reduction ˃2 kg/week during the last month
• Pregnancy or breastfeeding
• Regular strong physical activity with ≥1h/day
• High alcohol intake a weekly intake of ˃7 units for women and ˃14units for men
• Excess consumption of total fat ˃35% of daily calories
• Consumption of saturated fatty acid ˃10% of daily calories
• Cholesterol intake ˃300mg/day

• Minimum Eligible Age: 20 Years
• Maximum Eligible Age: 35 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Eastern Mediterranean University

OTHER

Sponsor Role: lead

Responsible Party

Fatma Hülyam Eren

Instructor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Tanju Besler, Prof.

Role: STUDY_CHAIR

Eastern Mediterranean University

Locations

Eastern Mediterrenean University

Famagusta, , Cyprus

Countries

Cyprus

Other Identifiers

EasternMedU

Identifier Type: -

Identifier Source: org_study_id